Benjamin E. Clifton
Australian National University
2 Papers
2 Citations
Benjamin E. Clifton is an academic researcher from Australian National University. The author has contributed to research in topics: Allele & Acquired immune system. The author has an hindex of 2, co-authored 2 publications.
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Papers
Denisovan, modern human and mouse TNFAIP3 alleles tune A20 phosphorylation and immunity.
Nathan W. Zammit,Nathan W. Zammit,Owen M. Siggs,Owen M. Siggs,Paul Gray,Keisuke Horikawa,David B. Langley,David B. Langley,Stacey N. Walters,Stacey N. Walters,Stephen R. Daley,Stephen R. Daley,Claudia Loetsch,Joanna Warren,Joanna Warren,Jin Yan Yap,Daniele Cultrone,Daniele Cultrone,Amanda J. Russell,Elisabeth K. Malle,Jeanette E. Villanueva,Mark J. Cowley,Mark J. Cowley,Velimir Gayevskiy,Marcel E. Dinger,Marcel E. Dinger,Robert Brink,Robert Brink,David Zahra,David Zahra,Geeta Chaudhri,Gunasegaran Karupiah,Gunasegaran Karupiah,Belinda Whittle,Carla M. Roots,Edward M. Bertram,Michiko Yamada,Yogesh Jeelall,Anselm Enders,Benjamin E. Clifton,Peter D. Mabbitt,Colin J. Jackson,Susan R. Watson,Craig N. Jenne,Craig N. Jenne,Lewis L. Lanier,Tim Wiltshire,Matthew H. Spitzer,Matthew H. Spitzer,Garry P. Nolan,Frank Schmitz,Frank Schmitz,Alan Aderem,Benjamin T. Porebski,Ashley M. Buckle,Derek W. Abbott,John B. Ziegler,Maria E. Craig,Maria E. Craig,Paul Z. Benitez-Aguirre,Juliana Teo,Stuart G. Tangye,Stuart G. Tangye,Cecile King,Cecile King,Melanie Wong,Murray P. Cox,Wilson Phung,Jia Tang,Wendy Sandoval,Ingrid E. Wertz,Daniel Christ,Daniel Christ,Christopher C. Goodnow,Christopher C. Goodnow,Shane T. Grey,Shane T. Grey +76 more
TL;DR: Genetic analyses of anatomically modern humans, extinct Denisovan hominins and mice revealed a TNFAIP3 allelic series with alterations in the encoded immune response inhibitor A20, which lower A20 activity and increase autoinflammatory responses.
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Phospho-tuning immunity through Denisovan, modern human and mouse TNFAIP3 gene variants
Nathan W. Zammit,Owen M. Siggs,Owen M. Siggs,Paul Gray,Paul Gray,Keisuke Horikawa,Stephen R. Daley,David B. Langley,Daniele Cultrone,Elisabeth K. Malle,Stacey N. Walters,Jeanette E. Villanueva,Joanna Warren,Amanda J. Russell,Mark J. Cowley,Mark J. Cowley,Velimir Gayevskiy,Marcel E. Dinger,Marcel E. Dinger,Claudia Loetsch,Cecile King,Robert Brink,David Zahra,Geeta Chaudhri,Gunasegaran Karupiah,Belinda Whittle,Carla M. Roots,Edward M. Bertram,Michiko Yamada,Yogesh Jeelall,Anselm Enders,Benjamin E. Clifton,Peter D. Mabbitt,Colin J. Jackson,Susan R. Watson,Craig N. Jenne,Lewis L. Lanier,Tim Wiltshire,Matthew H. Spitzer,Garry P. Nolan,Frank Schmitz,Alan Aderem,Benjamin T. Porebski,Ashley M. Buckle,Derek W. Abbott,John B. Ziegler,John B. Ziegler,Maria E. Craig,Maria E. Craig,Paul Z. Benitez-Aguirre,Juliana Teo,Melanie Wong,Murray P. Cox,Wilson Phung,Ingrid E. Wertz,Daniel Christ,Daniel Christ,Christopher C. Goodnow,Christopher C. Goodnow,Shane T. Grey,Shane T. Grey +60 more
TL;DR: Genetic analyses of anatomically modern humans, extinct Denisovan hominins, and mice revealed a series of missense variants in the immune response inhibitor A20, substituting non-catalytic residues of the ubiquitin protease domain to diminish IκB-dependent phosphorylation and activation of A20.