Benjamin Chadwick
Icahn School of Medicine at Mount Sinai
9 Papers
29 Citations
Benjamin Chadwick is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Dendritic spine & Estrous cycle. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Benjamin Chadwick include Skidmore College.
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Papers
Cannabis Use during Adolescent Development: Susceptibility to Psychiatric Illness.
TL;DR: Given the vulnerable nature of adolescent neurodevelopment and the persistent changes that follow early cannabis exposure, the experimental findings outlined should be carefully considered by policymakers and measures should be taken to reduce cannabis use among teens.
Rac1 is essential in cocaine-induced structural plasticity of nucleus accumbens neurons
David M. Dietz,HaoSheng Sun,Mary Kay Lobo,Michael E. Cahill,Benjamin Chadwick,Virginia Gao,Ja Wook Koo,Michelle S. Mazei-Robison,Caroline Dias,Ian Maze,Diane M. Damez-Werno,Karen C. Dietz,Kimberly N. Scobie,Deveroux Ferguson,Daniel J. Christoffel,Yoko H. Ohnishi,Georgia E. Hodes,Yi Zheng,Rachael L. Neve,Klaus M. Hahn,Scott J. Russo,Eric J. Nestler +21 more
TL;DR: It is shown that repeated exposure to cocaine negatively regulates the active form of Rac1, a small GTPase that controls actin remodeling in other systems, and that Rac1 signaling mediates structural and behavioral plasticity in response to cocaine exposure.
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Adolescent exposure to Δ9-tetrahydrocannabinol alters the transcriptional trajectory and dendritic architecture of prefrontal pyramidal neurons.
Michael L. Miller,Benjamin Chadwick,Dara L. Dickstein,Immanuel Purushothaman,Gabor Egervari,Tanni Rahman,Chloe Tessereau,Chloe Tessereau,Patrick R. Hof,Panos Roussos,Panos Roussos,Panos Roussos,Li Shen,Mark G. Baxter,Yasmin L. Hurd,Yasmin L. Hurd +15 more
TL;DR: Overall, adolescent THC exposure altered the morphological and transcriptional trajectory of PFC pyramidal neurons, which could enhance vulnerability to psychiatric disorders.
Epigenetic basis of opiate suppression of Bdnf gene expression in the ventral tegmental area
Ja Wook Koo,Michelle S. Mazei-Robison,Quincey LaPlant,Gabor Egervari,Kevin M Braunscheidel,Danielle N. Adank,Deveroux Ferguson,Jian Feng,HaoSheng Sun,Kimberly N. Scobie,Diane M. Damez-Werno,Efrain Ribeiro,Catherine Jensen Pena,Deena M. Walker,Rosemary C. Bagot,Michael E. Cahill,Sarah Ann R. Anderson,Benoit Labonté,Georgia E. Hodes,Heidi A. Browne,Benjamin Chadwick,Alfred J. Robison,Vincent Vialou,Caroline Dias,Zachary S. Lorsch,Ezekiell Mouzon,Mary Kay Lobo,David M. Dietz,Scott J. Russo,Rachael L. Neve,Yasmin L. Hurd,Eric J. Nestler +31 more
TL;DR: It is found that morphine suppressed binding of phospho-CREB (cAMP response element binding protein) to Bdnf promoters in VTA, which resulted from enrichment of trimethylated H3K27 at the promoters, and that decreased NURR1 (nuclear receptor related-1) expression also contributed to BDNf repression and associated behavioral plasticity to morphine.
Adolescent cannabinoid exposure attenuates adult female sexual motivation but does not alter adulthood CB1R expression or estrous cyclicity.
TL;DR: It is suggested that the endocannabinoid system may play a role in the maturation of neuroendocrine axes and adult female reproductive behavior, and that chronic exposure to cannabinoids during adolescence disrupts these neurodevelopmental processes.
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