Ben Chen
Fudan University
12 Papers
33 Citations
Ben Chen is an academic researcher from Fudan University. The author has contributed to research in topics: Cofilin & Monoclonal antibody. The author has an hindex of 6, co-authored 12 publications.
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Papers
Characterization of neutralizing antibody with prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys.
Shuang Wang,Yun Peng,Rongjuan Wang,Shasha Jiao,Min Wang,Weijin Huang,Chao Shan,Wen Jiang,Zepeng Li,Chunying Gu,Ben Chen,Xue Hu,Yanfeng Yao,Juan Min,Huajun Zhang,Ying Chen,Ge Gao,Peipei Tang,Gang Li,An Wang,Lan Wang,Jinchao Zhang,Shuo Chen,Xun Gui,Zhiming Yuan,Datao Liu +25 more
TL;DR: A monoclonal antibody, MW05, with SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor is reported.
Both NMDA and non-NMDA receptors mediate glutamate stimulation induced cofilin rod formation in cultured hippocampal neurons.
TL;DR: The results for the first time demonstrate the dynamic cofilin rod formation pattern under stress stimulation in detail by time lapse imaging, revealing a novel time course of excitotoxicity induced neuronal damage and indicate a potential target of neuropathy treatment of neurodegenerative diseases.
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Increased half-life and enhanced potency of Fc-modified human PCSK9 monoclonal antibodies in primates.
Yijun Shen,Hua Li,Li Zhao,Gang Li,Ben Chen,Guo Qingsong,Gao Bei,Jinsong Wu,Tong Yang,Li Jin,Yong Su +10 more
TL;DR: It is demonstrated that Fc-modified anti-PCKS9 antibodies may enable less frequent or lower dosing of antibodies by improved recycling into the blood by increased binding to FcRn, resulting in prolonged serum half-life and enhanced efficacy in vivo.
Bilateral internal carotid arteries ligation temporary impairs brain vasculaturev in young rats.
TL;DR: The BICL hypoperfusion model in young rats showed that the brain functional vascular area was impaired initially in certain brain regions after the artery ligation, but likely to be quickly self-recovered late after.
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An antibody-dependent enhancement (ADE) activity eliminated neutralizing antibody with potent prophylactic and therapeutic efficacy against SARS-CoV-2 in rhesus monkeys
Shuang Wang,Yun Peng,Rongjuan Wang,Shasha Jiao,Min Wang,Weijin Huang,Chao Shan,Wen Jiang,Zepeng Li,Chunying Gu,Ben Chen,Xue Hu,Yanfeng Yao,Juan Min,Huajun Zhang,Ying Chen,Ge Gao,Peipei Tang,Gang Li,An Wang,Lan Wang,Shuo Chen,Xun Gui,Jinchao Zhang,Zhiming Yuan,Datao Liu +25 more
TL;DR: A monoclonal antibody, MW05, is reported showing high SARS-CoV-2 neutralizing activity by disrupting the interaction of receptor binding domain (RBD) with angiotensin-converting enzyme 2 (ACE2) receptor by introducing the LALA mutation to the Fc region (MW05/LALA).
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