Belinda Whittle
Australian National University
46 Papers
294 Citations
Belinda Whittle is an academic researcher from Australian National University. The author has contributed to research in topics: Mutation & Biology. The author has an hindex of 27, co-authored 46 publications.
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Papers
A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity
Carola G. Vinuesa,Matthew C. Cook,Constanza Angelucci,Vicki Athanasopoulos,Lixin Rui,Kim M. Hill,Di Yu,Heather Domaschenz,Belinda Whittle,Teresa Lambe,Ian Roberts,Richard R. Copley,John I. Bell,Richard J. Cornall,Christopher C. Goodnow +14 more
TL;DR: The mouse genome is systematically screened for autoimmune regulators to isolate a mouse strain, sanroque, with severe autoimmune disease resulting from a single recessive defect in a previously unknown mechanism for repressing antibody responses to self.
900
Identification of phenotypically and functionally heterogeneous mouse mucosal-associated invariant t cells using MR1 tetramers
Azad Rahimpour,Hui-Fern Koay,Anselm Enders,Rhiannon Clanchy,Sidonia B G Eckle,Bronwyn S. Meehan,Zhenjun Chen,Belinda Whittle,Ligong Liu,David P. Fairlie,Christopher C. Goodnow,James McCluskey,Jamie Rossjohn,Jamie Rossjohn,Adam P Uldrich,Daniel G. Pellicci,Dale I. Godfrey +16 more
TL;DR: This work uses MR1 tetramers to characterize the heterogeneous population of mouse MAIT cells and finds a close resemblance to their human counterparts, which will provide the foundation for further investigation ofMAIT cells in health and disease.
Dock8 mutations cripple B cell immunological synapses, germinal centers and long-lived antibody production.
Katrina L. Randall,Katrina L. Randall,Teresa Lambe,Andy L Johnson,Andy L Johnson,Bebhinn Treanor,Edyta M. Kucharska,Heather Domaschenz,Belinda Whittle,Lina E. Tze,Anselm Enders,Tanya L. Crockford,Tiphaine Bouriez-Jones,Duncan Alston,Jason G. Cyster,Michael J. Lenardo,Fabienne Mackay,Elissa K. Deenick,Stuart G. Tangye,Tyani D. Chan,Tahra Camidge,Robert Brink,Carola G. Vinuesa,Facundo D. Batista,Richard J. Cornall,Christopher C. Goodnow +25 more
TL;DR: Humoral immunodeficiency due to Dock8 mutation provides evidence that organization of the immunological synapse is critical for signaling the survival of B cell subsets required for long-lasting immunity.
Comparison of predicted and actual consequences of missense mutations
Lisa A. Miosge,Matthew A. Field,Yovina Sontani,Vicky Cho,Simon Johnson,Anna Palkova,Bhavani Balakishnan,Rong Liang,Yafei Zhang,Stephen Aplin Lyon,Bruce Beutler,Belinda Whittle,Edward M. Bertram,Anselm Enders,Christopher C. Goodnow,Christopher C. Goodnow,T. Daniel Andrews +16 more
TL;DR: For de novo or low-frequency missense mutations found by genome sequencing, half those inferred as deleterious correspond to nearly neutral mutations that have little impact on the clinical phenotype of individual cases but will nevertheless become subject to purifying selection.
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ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes
Mehmet Yabas,Charis E Teh,Sandra Frankenreiter,Dennis Lal,Carla M. Roots,Belinda Whittle,Daniel T Andrews,Yafei Zhang,Narci C. Teoh,Jonathan Sprent,Jonathan Sprent,Lina E. Tze,Edyta M. Kucharska,Jennifer Kofler,Geoffrey C Farell,Stefan Bröer,Christopher C. Goodnow,Anselm Enders +17 more
TL;DR: A previously unknown X-linked B cell–deficiency syndrome in mice caused by mutations in Atp11c is described, which encodes a member of the P4 ATPase family thought to serve as 'flippases' that concentrate aminophospholipids in the cytoplasmic leaflet of cell membranes.