Beka Solomon
Tel Aviv University
159 Papers
2.7K Citations
Beka Solomon is an academic researcher from Tel Aviv University. The author has contributed to research in topics: Epitope & Monoclonal antibody. The author has an hindex of 33, co-authored 156 publications.
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Papers
Disaggregation of Alzheimer β-amyloid by site-directed mAb
TL;DR: Findings give hints on how to convert in vivo senile plaques into nontoxic, diffuse components and may have therapeutic interest for those studying Alzheimer disease and other human diseases related to amyloidogenic properties of physiological peptides and proteins.
551
Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide.
TL;DR: It is found that the mAs prevent the aggregation of beta-amyloid peptide and that the inhibitory effect appears to be related to the localization of the antibody-binding sites and the nature of the aggregating agents.
Immunization against Alzheimer's β-amyloid plaques via EFRH phage administration
TL;DR: Development of an immunization procedure for the production of effective anti-aggregating beta-amyloid antibodies based on filamentous phages displaying the EFRH peptide as specific and nontoxic antigen suggests the feasibility of vaccination against Alzheimer's disease.
237
Modulation of Alzheimer’s β-amyloid neurotoxicity by site-directed single-chain antibody
TL;DR: The ability of antibody 508F(Fv) to dissolve already-formed betaA fibrils makes it a good candidate for intracellular expression and modulation of APP processing as the first step towards the production of therapeutic protection molecules for Alzheimer's disease treatment.
177
N-terminal EFRH sequence of Alzheimer's β-amyloid peptide represents the epitope of its anti-aggregating antibodies
TL;DR: It is confirmed that the peptide EFRH which is located at positions 3-6 within beta-amyloid peptide represents the sequential epitope of mAbs 6C6 and 10D5.
166