Beiling Chen
University of California, Los Angeles
10 Papers
58 Citations
Beiling Chen is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 6, co-authored 7 publications. Previous affiliations of Beiling Chen include UCLA Medical Center.
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Papers
Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy.
Terry J. Smith,Chieh Chih Tsai,Mei Ju Shih,Shanli Tsui,Beiling Chen,Rui Han,Vibha Naik,Chris S. King,Chris Press,Shweta Kamat,Robert A. Goldberg,Richard P. Phipps,Raymond S. Douglas,Andrew G. Gianoukakis +13 more
TL;DR: The laboratory group has focused over the last several years on defining the peculiarities of the human orbital fibroblasts as a strategy for shedding more light on the pathologies occurring in TAO, reasoned that unique properties of these cells might ultimately prove the basis for why the manifestations of Graves' disease occur in an anatomically selective manner.
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Interleukin-4 induces 15-lipoxygenase-1 expression in human orbital fibroblasts from patients with Graves disease. Evidence for anatomic site-selective actions of Th2 cytokines.
Beiling Chen,Shanli Tsui,Shanli Tsui,William E. Boeglin,Raymond S. Douglas,Raymond S. Douglas,Alan R. Brash,Terry J. Smith,Terry J. Smith +8 more
TL;DR: It is suggested that orbital connective tissues may represent a site of localized 15-hydroxyeicosatetraenoic acid generation resulting from cell type-specific 15-LOX-1 mRNA stabilization by IL-4, and may have relevance to the pathogenesis of orbital Graves disease.
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Divergent Sp1 protein levels may underlie differential expression of UDP-glucose dehydrogenase by fibroblasts: role in susceptibility to orbital Graves disease.
TL;DR: It is reported that orbital fibroblasts express higher levels of UGDH than do those from skin, apparently the result of greater constitutive Sp1, which may underlie susceptibility of the orbit to localized overproduction of hyaluronan in Graves disease.
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FLI1 regulates inflammation-associated genes to accelerate leukemogenesis.
Beiling Chen,Danmei Sheng,Chunlin wang,Wuling Liu,An-Ling Hu,Xiao Xiao,Babu Gajendran,Jian Gao,Jifen Hu,Klarke M. Sample,Eldad Zacksenhaus,Yaacov Ben-David +11 more
TL;DR: In this article , the ETS related transcription factor Fli-1 is involved in the induction and progression of various cancers; yet its role in inflammation is not well-defined.
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Jak2 Dampens the Induction by IL-1β of Prostaglandin Endoperoxide H Synthase 2 Expression in Human Orbital Fibroblasts: Evidence for Divergent Influence on the Prostaglandin E2 Biosynthetic Pathway
TL;DR: It is reported that the induction of PGHS-2 by IL-1β is dramatically enhanced and prolonged when Jak2 signaling is abrogated, either with the specific inhibitor AG490 or by transiently transfecting fibroblasts with a dominant negative mutant Jak2.
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