Beate Kaufmann
University of Freiburg
4 Papers
13 Citations
Beate Kaufmann is an academic researcher from University of Freiburg. The author has contributed to research in topics: Biology & Infectivity. The author has an hindex of 4, co-authored 4 publications.
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Papers
Modularized CRISPR/dCas9 effector toolkit for target-specific gene regulation.
Michael Agne,Ilona Blank,Alica J. Emhardt,Christoph G Gäbelein,Fenja Gawlas,Nadine Gillich,Patrick Gonschorek,Thomas J Juretschke,Stefan D Krämer,Natalie Louis,Anne Müller,Alina Rudorf,Lisa M Schäfer,Manuel C. Scheidmann,Lisa J Schmunk,Philipp Schwenk,Maximilian R Stammnitz,Philipp M Warmer,Wilfried Weber,Adrian Fischer,Beate Kaufmann,Hanna J. Wagner,Gerald Radziwill +22 more
TL;DR: A standardized toolkit utilizing an engineered CRISPR/Cas9 system that enables customizable gene regulation in mammalian cells is developed, which comprises a modular RNAimer plasmid, which encodes the required noncoding RNA components.
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Modular adeno-associated virus (rAAV) vectors used for cellular virus-directed enzyme prodrug therapy.
Sven Hagen,Tobias Baumann,Hanna J. Wagner,Volker Morath,Beate Kaufmann,Adrian Fischer,Stefan Bergmann,Patrick Schindler,Katja M. Arndt,Kristian M. Müller +9 more
TL;DR: This work fusing rAAV-2 capsids with two modular targeting molecules specific for a cancer cell-surface marker (EGFR) while simultaneously including an affinity tag (His-tag) in a surface-exposed loop to demonstrate tumor marker specific transduction and prodrug-dependent apoptosis of cancer cells.
Evaluation of bicinchoninic acid as a ligand for copper(I)-catalyzed azide–alkyne bioconjugations
Erik H. Christen,Erik H. Christen,Raphael J. Gübeli,Beate Kaufmann,Lars Merkel,Ronald Schoenmakers,Nediljko Budisa,Martin Fussenegger,Wilfried Weber,Birgit Wiltschi +9 more
TL;DR: It is demonstrated that the BCA-Cu(I)-complex represents an efficient catalyst for the conjugation of fluorophores or biotin to alkyne- or azide-functionalized proteins resulting in increased or at least equal reaction yields compared to commonly used catalysts.
A chemical switch for controlling viral infectivity.
Maximilian Hörner,Beate Kaufmann,Gabriella Cotugno,Ellen Wiedtke,Hildegard Büning,Dirk Grimm,Wilfried Weber +6 more
TL;DR: This work presents the first chemically triggered switch for controlling the infectivity of adeno-associated viral vectors, which is fundamental to the emergence of synthetic biology and the development of biomedical applications.
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