Beat Kunz
University of Zurich
39 Papers
595 Citations
Beat Kunz is an academic researcher from University of Zurich. The author has contributed to research in topics: Biology & Agrin. The author has an hindex of 21, co-authored 37 publications.
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Papers
Neurotrypsin cleaves agrin locally at the synapse
Alexander Stephan,José María Mateos,Serguei Kozlov,Paolo Cinelli,Andreas D. Kistler,Stefan Hettwer,Thomas Rülicke,Peter Streit,Beat Kunz,Peter Sonderegger +9 more
TL;DR: Morphological analyses indicate that neu rotrypsin is contained in presynaptic terminals and externalized in association with synaptic activity, while agrin is localized to the extracellular space at or in the vicinity of the synapse.
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Cell adhesion molecules NgCAM and axonin-1 form heterodimers in the neuronal membrane and cooperate in neurite outgrowth promotion.
Andrea Buchstaller,Stefan Kunz,Philipp Berger,Beat Kunz,Urs Ziegler,Christoph Rader,Peter Sonderegger +6 more
TL;DR: It is concluded that neurite outgrowth on an NgCAM substratum depends on two essential interactions of growth cone NgCAMI and a cis-interaction with axonin-1 residing in the same growth cone membrane.
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Neurite Fasciculation Mediated by Complexes of Axonin-1 and Ng Cell Adhesion Molecule
Stefan Kunz,Marianne Spirig,Claudia Ginsburg,Andrea Buchstaller,Philipp Berger,Rainer B. Lanz,Christoph Rader,Lorenz Vogt,Beat Kunz,Peter Sonderegger +9 more
TL;DR: The enhanced neurite fasciculation after overexpression of NgC AM by adenoviral vectors indicates that NgCAM is the limiting component for the formation of the axonin-12/NgCAM2 complexes and, thus, neurite Fasciculation in DRG neurons.
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Coincident Pre- and Postsynaptic Activation Induces Dendritic Filopodia via Neurotrypsin-Dependent Agrin Cleavage
Kazumasa Matsumoto-Miyai,Ewa Sokolowska,Andreas Zurlinden,Christine E. Gee,Daniel Lüscher,Stefan Hettwer,Jens Wölfel,Ana Paula Ladner,Jeanne Ster,Urs Gerber,Thomas Rülicke,Beat Kunz,Peter Sonderegger +12 more
TL;DR: The activity-dependent formation of dendritic filopodia is abolished in hippocampal neurons from neurotrypsin-deficient mice and may be instrumental for a Hebbian organization and remodeling of synaptic circuits in the CNS.
110
Specific proteolytic cleavage of agrin regulates maturation of the neuromuscular junction
Marc Bolliger,Andreas Zurlinden,Daniel Lüscher,Lukas Bütikofer,Olga Shakhova,Maura Francolini,Serguei Kozlov,Paolo Cinelli,Alexander Stephan,Andreas D. Kistler,Thomas Rülicke,Pawel Pelczar,Birgit Ledermann,Guido Francesco Fumagalli,Sergio M. Gloor,Beat Kunz,Peter Sonderegger +16 more
TL;DR: It is found that the progress of plaque-to-pretzel maturation is regulated by agrin, and agrin cleavage at its proteolytic α- and β-sites by an as-yet-unspecified protease is characterized as a regulatory access for relieving the agrin-dependent constraint on endplate reorganization during NMJ maturation.
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