Beat Flühmann
Hoffmann-La Roche
15 Papers
9 Citations
Beat Flühmann is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 3, co-authored 4 publications.
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Papers
Critical roles of PPARβ/δ in keratinocyte response to inflammation
Nguan Soon Tan,Liliane Michalik,Noa Noy,Noa Noy,Rubina Yasmin,Corinne Pacot,Corinne Pacot,Manuel Heim,Beat Flühmann,Béatrice Desvergne,Walter Wahli +10 more
TL;DR: It is shown, by use of cultures of primary keratinocytes from wild-type and PPAR/ �/� mice, that such signals including TNF- and IFN-, induce keratinocyte differentiation and this effect is also observed in vivo during wound healing after an injury.
Phytanic acid, a natural peroxisome proliferator-activated receptor (PPAR) agonist, regulates glucose metabolism in rat primary hepatocytes
Manuel Heim,James B. Johnson,Franziska Boess,Igor Bendik,Peter Weber,Willi Hunziker,Beat Flühmann +6 more
TL;DR: It is demonstrated that phytanic acid acts via different PPAR isoforms to modulate expression of genes involved in glucose metabolism, thus suggesting a potential role of phytic acid in the management of insulin resistance.
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Criticality of Surface Characteristics of Intravenous Iron–Carbohydrate Nanoparticle Complexes: Implications for Pharmacokinetics and Pharmacodynamics
TL;DR: The surface chemistry differences between the iron–carbohydrate complexes results in significant differences in in vivo pharmacokinetic and pharmacodynamic profiles as well as adverse event profiles, demonstrating that the entire iron– carbohydrate complex furnishes the pharmacologic action for these complex products.
Kupffer Cells and Blood Monocytes Orchestrate the Clearance of Iron–Carbohydrate Nanoparticles from Serum
Tasneem Arsiwala,A. Vogt,Amy E. Barton,Vania Manolova,Felix Funk,Beat Flühmann,Martin F. Bachmann +6 more
TL;DR: Gene expression profiling indicated that C-C chemokine receptor type 5 (CCR5) might be involved in monocyte recruitment to the liver, confirmed by pharmaceutical inhibition of CCR5 and Liver KCs play a pivotal role in the clearance and storage of IV iron and KCs appear to be supported by the expanded blood monocyte population.
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Need for Expansion of Pharmacy Education Globally for the Growing Field of Nanomedicine
Amy E. Barton,Gerrit Borchard,Matthias G. Wacker,Giorgia Pastorin,Imran Saleem,Shaqil H. Chaudary,Tamer Elbayoumi,Zhigang Zhao,Beat Flühmann +8 more
TL;DR: An overview of nanomedicine education within the selection of pharmacy programs globally is provided, the current regulatory challenges are discussed, and different approaches to incorporate nanomediine science in pharmacy programs around the world are described.