Bea Pauwels
University of Antwerp
32 Papers
217 Citations
Bea Pauwels is an academic researcher from University of Antwerp. The author has contributed to research in topics: Gemcitabine & Cell cycle. The author has an hindex of 16, co-authored 32 publications.
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Papers
Review: Implications of In Vitro Research on the Effect of Radiotherapy and Chemotherapy Under Hypoxic Conditions
TL;DR: An overview of preclinical and clinical research on radiotherapy, chemotherapy, and chemoradiation under hypoxic conditions and the effects of hypoxia per se on some critical biological pathways is focused on.
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Comparison of the sulforhodamine B assay and the clonogenic assay for in vitro chemoradiation studies.
Bea Pauwels,Annelies E. C. Korst,Christel De Pooter,Greet G. O. Pattyn,Hilde A. J. Lambrechts,Marc Baay,Filip Lardon,Jan B. Vermorken +7 more
TL;DR: The SRB assay was shown to be as useful as the more traditional CA for research on chemotherapy/radiotherapy interactions in cell lines with moderate radiosensitivity and will be used for more extensive in vitro research on radiosensitizing compounds in these cell lines.
138
Isolated lung perfusion with gemcitabine in a rat: pharmacokinetics and survival
Bart P. van Putte,Jeroen M.H. Hendriks,Sander Romijn,Bea Pauwels,Godehard Friedel,Gunther Guetens,Ernst A. de Bruijn,Paul Van Schil +7 more
TL;DR: GCB ILuP is well-tolerated to a maximum dose of 320 mg/kg and results in significantly higher GCB lung levels with undetectable serum levels compared to iv treatment.
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Unraveling the Mechanism of Radiosensitization by Gemcitabine: The Role of TP53
Bea Pauwels,Annelies E. C. Korst,Veronique Andriessen,Marc Baay,Greet G. O. Pattyn,Hilde A. J. Lambrechts,Christel De Pooter,Filip Lardon,Jan B. Vermorken +8 more
TL;DR: Using isogenic cell lines, it is shown that neither TP53 status nor the transfection procedure influenced the radiosensitizing effect of gemcitabine, and it is likely that TP53 protein does not play a crucial role in the radiosensingitizing mechanism of gem citabine.
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The radiosensitising effect of difluorodeoxyuridine, a metabolite of gemcitabine, in vitro
Bea Pauwels,Annelies E. C. Korst,Hilde A. J. Lambrechts,Greet G. O. Pattyn,Christel De Pooter,Filip Lardon,Jan B. Vermorken +6 more
TL;DR: In this paper, the authors investigated the radiosensitising potential of difluorodeoxyuridine (dFdU) in vitro and found that dFdUs caused a clear concentration-dependent radiosENSitising effect in both ECV304 and H292 cells.
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