Basel Dabbas
McGill University
5 Papers
23 Citations
Basel Dabbas is an academic researcher from McGill University. The author has contributed to research in topics: Calcitriol receptor & Regulation of gene expression. The author has an hindex of 5, co-authored 5 publications.
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Papers
Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease
Tian-Tian Wang,Basel Dabbas,David Laperrière,Ari J. Bitton,Hafid Soualhine,Luz E. Tavera-Mendoza,Serge Dionne,Marc J. Servant,Alain Bitton,Ernest G. Seidman,Sylvie Mader,Marcel A. Behr,John H. White +12 more
TL;DR: Hormonal vitamin D, 1,25-dihydroxyvitamin D3, robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells, providing strong molecular links between vitamin D deficiency and the genetics of Crohn disease, a chronic incurable inflammatory bowel condition.
409
Incorporation of histone deacetylase inhibition into the structure of a nuclear receptor agonist.
Luz E. Tavera-Mendoza,Tan Quach,Basel Dabbas,Jonathan Hudon,Xiaohong Liao,Ana Palijan,James L. Gleason,John H. White +7 more
TL;DR: The feasibility of combining HDAC inhibition with nuclear receptor agonism to enhance their therapeutic potential is demonstrated and triciferol, a hybrid molecule in which the 1,25D side chain was replaced with the dienyl hydroxamic acid of HDACi trichostatin A, is designed.
69
Vitamin D Receptor Agonist/Histone Deacetylase Inhibitor Molecular Hybrids
Marc Lamblin,Basel Dabbas,Russell Spingarn,Rodrigo Mendoza-Sanchez,Tian-Tian Wang,Beum-Soo An,Dao Chao Huang,Richard Kremer,John H. White,James L. Gleason +9 more
TL;DR: These bifunctional hybrids display in vitro antiproliferative activity against the AT84 squamous carcinoma cell line while lacking the in vivo hypercalcemic effects of 1,25D.
38
An o-Aminoanilide Analogue of 1α,25-Dihydroxyvitamin D3 Functions as a Strong Vitamin D Receptor Antagonist
Marc Lamblin,Russell Spingarn,Tian-Tian Wang,Melanie C. Burger,Basel Dabbas,Nicolas Moitessier,John H. White,James L. Gleason +7 more
TL;DR: An o-aminoanilide analogue of the hormonal form of vitamin D with a dienyl side chain that functions as a strong VDR antagonist is identified.
27
Transcription factors Sp1 and C/EBP regulate NRAMP1 gene expression
Etienne Richer,Etienne Richer,Carole G. Campion,Basel Dabbas,John H. White,Mathieu F. M. Cellier +5 more
TL;DR: This study implicates Sp1 and C/EBP factors in regulating the expression of the NRAMP1 gene in myeloid cells, which contributes to phagocyte‐autonomous antimicrobial defense mechanisms.