Basant Kumar Thakur
Hannover Medical School
40 Papers
973 Citations
Basant Kumar Thakur is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 17, co-authored 29 publications. Previous affiliations of Basant Kumar Thakur include University of Duisburg-Essen & Cornell University.
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Papers
Pancreatic cancer exosomes initiate pre-metastatic niche formation in the liver
Bruno Costa-Silva,Nicole M. Aiello,Allyson J. Ocean,Swarnima Singh,Haiying Zhang,Basant Kumar Thakur,Basant Kumar Thakur,Annette Becker,Ayuko Hoshino,Milica Tesic Mark,Henrik Molina,Jenny Xiang,Tuo Zhang,Till Martin Theilen,Guillermo García-Santos,Caitlin Williams,Yonathan Ararso,Yujie Huang,Gonçalo Rodrigues,Tang-Long Shen,Knut Jørgen Labori,Inger Marie Bowitz Lothe,Elin H. Kure,Jonathan M. Hernandez,Alexandre Doussot,Saya H. Ebbesen,Paul M. Grandgenett,Michael A. Hollingsworth,Maneesh Jain,Kavita Mallya,Surinder K. Batra,William R. Jarnagin,Robert E. Schwartz,Irina Matei,Héctor Peinado,Ben Z. Stanger,Jacqueline Bromberg,David Lyden,David Lyden +38 more
TL;DR: It is shown that PDAC-derived exosomes induce liver pre-metastatic niche formation in naive mice and consequently increase liver metastatic burden and suggests that exosomal MIF primes the liver for metastasis and may be a prognostic marker for the development of PDAC liver metastasis.
Extracellular Vesicles in Cancer: Cell-to-Cell Mediators of Metastasis
Annette Becker,Basant Kumar Thakur,Joshua Mitchell Weiss,Han Sang Kim,Han Sang Kim,Héctor Peinado,David Lyden +6 more
TL;DR: Clinically, EVs may be biomarkers and novel therapeutic targets for cancer progression, particularly for predicting and preventing future metastatic development.
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Use of double-stranded dna in exosomes: a novel biomarker in cancer detection
David Lyden,Hector Peinado Selgas,Haiying Zhang,Basant Kumar Thakur,Annette Becker,Jacqueline Bromberg +5 more
TL;DR: In this paper, the authors present methods of prognosing, treating, or managing treatment of cancer in a subject, which involve selecting a subject having cancer, obtaining, from the selected subject, a sample containing exosomes and isolating the double-stranded DNA from within the exosome.
917
Packaging and transfer of mitochondrial DNA via exosomes regulate escape from dormancy in hormonal therapy-resistant breast cancer
Pasquale Sansone,Claudia Savini,Ivana Kurelac,Qing Chang,Laura Benedetta Amato,Antonio Strillacci,Antonio Strillacci,Anna Stepanova,Luisa Iommarini,Chiara Mastroleo,Laura Daly,Alexander Galkin,Alexander Galkin,Basant Kumar Thakur,Nadine Soplop,Kunihiro Uryu,Ayuko Hoshino,Larry Norton,Massimiliano Bonafè,Monica Cricca,Giuseppe Gasparre,David Lyden,David Lyden,Jacqueline Bromberg,Jacqueline Bromberg +24 more
TL;DR: It is demonstrated that the horizontal transfer of mtDNA from EVs acts as an oncogenic signal promoting an exit from dormancy of therapy-induced cancer stem-like cells and leading to endocrine therapy resistance in OXPHOS-dependent breast cancer.
622
NAMPT is essential for the G-CSF–induced myeloid differentiation via a NAD + –sirtuin-1–dependent pathway
Julia Skokowa,Dan Lan,Basant Kumar Thakur,Fei Wang,Kshama Gupta,Gunnar Cario,Annette Müller Brechlin,Axel Schambach,Lars Hinrichsen,Gustav Meyer,Matthias Gaestel,Martin Stanulla,Qiang Tong,Karl Welte +13 more
TL;DR: A decisive role of the NAD+ metabolic pathway in G-CSF-triggered myelopoiesis is revealed and is revealed in healthy individuals and in individuals with severe congenital neutropenia.
206