Bas Brouwers
University of Cambridge
20 Papers
85 Citations
Bas Brouwers is an academic researcher from University of Cambridge. The author has contributed to research in topics: Furin & Proprotein convertase. The author has an hindex of 9, co-authored 18 publications. Previous affiliations of Bas Brouwers include Katholieke Universiteit Leuven & Medical Research Council.
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Papers
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity
Luca A. Lotta,Jacek Mokrosinski,Edson Mendes de Oliveira,Chen Li,Stephen J. Sharp,Jian'an Luan,Bas Brouwers,Vikram Ayinampudi,Nicholas Bowker,Nicola D. Kerrison,Vasileios Kaimakis,Diana Hoult,Isobel D. Stewart,Eleanor Wheeler,Felix R. Day,John R. B. Perry,Claudia Langenberg,Nicholas J. Wareham,I. Sadaf Farooqi +18 more
TL;DR: Protective associations were driven by MC4R variants exhibiting signaling bias toward β-arrestin recruitment and increased mitogen-activated protein kinase pathway activation, which may represent an effective strategy for weight loss and the treatment of obesity-related cardiometabolic diseases.
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Metabolic and Behavioural Phenotypes in Nestin-Cre Mice Are Caused by Hypothalamic Expression of Human Growth Hormone
Jeroen Declercq,Bas Brouwers,Vincent P. E. G. Pruniau,Pieter Stijnen,Geoffroy de Faudeur,Krizia Tuand,Sandra Meulemans,Lutgarde Serneels,Anica Schraenen,Frans Schuit,John W.M. Creemers +10 more
TL;DR: It is demonstrated that the unexpected expression of hGH in the hypothalamus of Nestin-Cre mice which is able to activate both the GH receptor and the prolactin receptor is consistent with reduced anxiety.
Human BDNF/TrkB variants impair hippocampal synaptogenesis and associate with neurobehavioural abnormalities.
Takuhiro Sonoyama,Lukas K. J. Stadler,Mingyan Zhu,Julia M. Keogh,Elana Henning,Fuki M. Hisama,Peter Kirwan,Magdalena Jura,Beata K. Blaszczyk,David C. DeWitt,Bas Brouwers,Marko Hyvönen,Inês Barroso,Florian T. Merkle,Suzanne M. Appleyard,Gary A. Wayman,I. Sadaf Farooqi +16 more
TL;DR: In this article, a de novo missense variant in BDNF and seven rare variants in Tropomyosin receptor kinase-B were identified in a large cohort of people with severe, childhood-onset obesity.
Phlorizin Pretreatment Reduces Acute Renal Toxicity in a Mouse Model for Diabetic Nephropathy
Bas Brouwers,Vincent P. E. G. Pruniau,Elisa J.G. Cauwelier,Frans Schuit,Evelyne Lerut,Nadine Ectors,Jeroen Declercq,John W.M. Creemers +7 more
TL;DR: Novel insights are provided into the mechanism of STZ toxicity in kidneys and a more efficient regime to induce DN with little or no toxic side effects is suggested.
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Quantitative mass spectrometry for human melanocortin peptides in vitro and in vivo suggests prominent roles for β-MSH and desacetyl α-MSH in energy homeostasis.
Peter Kirwan,Richard G. Kay,Bas Brouwers,Vicente Herranz Pérez,Magdalena Jura,Pierre Larraufie,Julie Jerber,Jason Pembroke,Theresa Bartels,Anne White,Fiona M. Gribble,Frank Reimann,I. Sadaf Farooqi,Stephen O'Rahilly,Florian T. Merkle +14 more
TL;DR: The findings challenge the assumed pre-eminence of α-MSH and suggest that in humans, d-α- MSH and β-MSh are likely to be the predominant physiological products acting on melanocortin receptors.
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