Bart H. Steiner
Icos
14 Papers
227 Citations
Bart H. Steiner is an academic researcher from Icos. The author has contributed to research in topics: P110δ & PI3K/AKT/mTOR pathway. The author has an hindex of 9, co-authored 14 publications.
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Papers
Structural and functional definition of the human chitinase chitin-binding domain.
Larry W. Tjoelker,Larry Gosting,Steve M. Frey,Christie L. Hunter,Hai Le Trong,Bart H. Steiner,Heather Brammer,Patrick W. Gray +7 more
TL;DR: Structural features of the minimal domain of human chitinase required for both specifically binding to and hydrolyzing insoluble ch itin are defined and relevant binding within the context of the fungal cell wall is demonstrated.
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Macrophage-Derived Chemokine and EBI1-Ligand Chemokine Attract Human Thymocytes in Different Stage of Development and Are Produced by Distinct Subsets of Medullary Epithelial Cells: Possible Implications for Negative Selection
Francesco Annunziato,Paola Romagnani,Lorenzo Cosmi,Chiara Beltrame,Bart H. Steiner,Elena Lazzeri,Carol J. Raport,Grazia Galli,Roberto Manetti,Carmelo Mavilia,Vittorio Vanini,David Chantry,Enrico Maggi,Sergio Romagnani +13 more
TL;DR: It is suggested that CD30L-expressing MDC-producing medullary epithelial cells attract CCR4- expressing thymocytes, thus favoring the CD30/CD30L interaction, and therefore the apoptosis, of cells that are induced to express CD30 by autoantigen activation.
2,4,6-Triaminopyrimidine as a Novel Hinge Binder in a Series of PI3Kδ Selective Inhibitors
Leena Patel,Jayaraman Chandrasekhar,Jerry Evarts,Aaron C. Haran,Carmen Ip,Joshua Kaplan,Musong Kim,David Koditek,Latesh Lad,Eve-Irene Lepist,Mary E. McGrath,Nikolai Novikov,Stephane Perreault,Kamal D. Puri,John R. Somoza,Bart H. Steiner,Kirk L. Stevens,Joseph Therrien,Jennifer Treiberg,Armando G. Villaseñor,Arthur Yeung,Gary Phillips +21 more
TL;DR: This medicinal chemistry effort culminated in the identification of 52, a potent and highly selective inhibitor of PI3Kδ that demonstrates efficacy in a rat model of arthritis.
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Effects of Isoform-Selective Phosphatidylinositol 3-Kinase Inhibitors on Osteoclasts: ACTIONS ON CYTOSKELETAL ORGANIZATION, SURVIVAL AND RESORPTION
Ryan P.P. Shugg,Ashley Thomson,Natsuko Tanabe,Adam Kashishian,Bart H. Steiner,Kamal D. Puri,Alexey Pereverzev,Brian J. Lannutti,Frank R. Jirik,S. Jeffrey Dixon,Stephen M. Sims +10 more
TL;DR: It is found that PI3Kδ regulates osteoclast morphology, actin cytoskeletal organization, and resorptive activity, and is an attractive target for anti-resorptive therapeutics.
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Discovery of Orally Efficacious Phosphoinositide 3-Kinase δ Inhibitors with Improved Metabolic Stability
Leena Patel,Jayaraman Chandrasekhar,Jerry Evarts,Kristen Forseth,Aaron C. Haran,Carmen Ip,Adam Kashishian,Musong Kim,David Koditek,Sandy Koppenol,Latesh Lad,Eve-Irene Lepist,Mary E. McGrath,Stephane Perreault,Kamal D. Puri,Armando G. Villaseñor,John R. Somoza,Bart H. Steiner,Joseph Therrien,Jennifer Treiberg,Gary Phillips +20 more
TL;DR: This work led to the discovery of 35, a highly selective inhibitor of PI3Kδ which displays an excellent pharmacokinetic profile and is efficacious in a rodent model of rheumatoid arthritis.
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