Barry E. Howard
United States Environmental Protection Agency
11 Papers
229 Citations
Barry E. Howard is an academic researcher from United States Environmental Protection Agency. The author has contributed to research in topics: Mutant & Pyrene. The author has an hindex of 7, co-authored 11 publications.
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Papers
Analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/- mouse lymphoma cells.
Martha M. Moore,Donald Clive,John C. Hozier,Barry E. Howard,A. Gail Batson,Nancy T. Turner,Jeffrey Sawyer +6 more
TL;DR: The inclusion of sigma mutants in the total induced mutant frequency, as well as distinguishing them as a separate subpopulation of TK-deficient mutants, is essential in obtaining maximum utility of the information provided by the L5178Y/TK+/- mouse lymphoma assay.
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Cytogenetic analysis of the L5178Y/TK+/− → TK−/− mouse lymphoma mutagenesis assay system
TL;DR: It seems likely that λ and σ mutants result from 2 different mutational mechanisms that may be distinguished on the basis of mutant colony morphology, possibly related to the type of chromosomal damage sustained.
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Research paperIn situ analysis of trifluorothymidine-resistant (TFTr) mutants of L5178Y/TK+/− mouse lymphoma cells☆
TL;DR: In this paper, the authors analyzed TFTr mutants of L5178Y/TK+/− mouse lymphoma cells and analyzed the properties of σ and λ mutants.
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The utilization of trifluorothymidine (TFT) to select for thymidine kinase-deficient (TK−/−) mutants from L5178Y/TK+/− mouse lymphoma cells
TL;DR: Reconstruction analyses of effective TK-/- mutant recovery indicate that TFT can be used to recover mutants from significantly higher densities of TK+/- cells than can BUdR.
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•Journal Article
Mutagenesis and Morphological Transformation of Mammalian Cells by a Non-Bay-Region Polycyclic Cyclopenta(cd)pyrene and Its 3,4-Oxide
Avram Gold,Stephen Nesnow,Martha M. Moore,Helen Garland,Gaynelle Curtis,Barry E. Howard,Deloris Graham,Eric Eisenstadt +7 more
TL;DR: Results suggest that cyclopenta(cd)pyrene 3,4-oxide may be an ultimate mutagenic form of the parent hydrocarbon.
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