Barry E. Argent

TL;DR: A small conductance ion channel that typically occurs in clusters on the apical plasma membrane of pancreatic duct cells is identified and coupling of this channel to a chloride/bicarbonate exchanger would provide a mechanism for electrogenic bicarbonates secretion by pancreatIC duct cells.

TL;DR: It is concluded that both CaCC and the Ca2+ signal are increased in CF airway epithelia, and that they contribute to acute but not basal regulation of ASL height.

TL;DR: Evidence is presented suggesting that these cAMP-regulated currents are carried by cystic fibrosis transmembrane conductance regulator (CFTR) chloride channels, Physiologically, these CFTR channels act in parallel with chloride-bicarbonates exchangers to facilitate bicarbonate secretion across the apical plasma membrane of the duct cell.

TL;DR: It is concluded that the HCO3− secretion stimulated by low concentrations of bile acids acts to protect the pancreas against toxic bile, whereas inhibition of HCO2− secretion by high concentrations of BAPTA-AM may contribute to the progression of acute pancreatitis.