Barbara J. Sahakian
University of Cambridge
657 Papers
5.6K Citations
Barbara J. Sahakian is an academic researcher from University of Cambridge. The author has contributed to research in topics: Cognition & Medicine. The author has an hindex of 145, co-authored 612 publications. Previous affiliations of Barbara J. Sahakian include University of Westminster & Shanghai Jiao Tong University.
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Papers
Methylphenidate-mediated motor control network enhancement in patients with traumatic brain injury.
Charlie L. Dorer,Anne E. Manktelow,Judith Allanson,Barbara J. Sahakian,John D. Pickard,Andrew Bateman,David K. Menon,Emmanuel Stamatakis +7 more
TL;DR: The findings suggest that residual functionality in patients with TBI may be enhanced by a single dose of methylphenidate, as reflected in the fMRI findings.
l-Dopa medication remediates cognitive inflexibility, but increases impulsivity in patients with Parkinson’s disease
TL;DR: Findings that dopaminergic medication improves or impairs cognitive performance depending on the nature of the task and the basal level of dopamine function in underlying cortico-striatal circuitry are replicated and extended.
Innovative methods for improving cognition, motivation and wellbeing in schizophrenia.
TL;DR: National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre (Mental Health Theme)
Shared alterations in resting-state brain connectivity in adults with attention-deficit/hyperactivity disorder and their unaffected first-degree relatives.
TL;DR: Brain network organisation can potentially be employed as an important neurocognitive trait to enhance statistical power of genetic studies in ADHD and as a surrogate efficacy endpoint in the development of novel pharmaceuticals.
Imaging of cerebral blood flow and metabolism in brain injury in the ICU.
John D. Pickard,Peter J. Hutchinson,Jonathan P. Coles,Luzius A. Steiner,Atholl Johnston,Tim D. Fryer,Martin R. Coleman,Peter Smielewski,D. A. Chatfield,Franklin I. Aigbirhio,Guy B. Williams,Kenneth Rice,John C. Clark,C.H. Salmond,Barbara J. Sahakian,Peter G. Bradley,T. A. Carpenter,Raymond Salvador,Alonso Pena,Jonathan H. Gillard,A. S. Cunningham,Stefan K. Piechnik,Marek Czosnyka,David K. Menon +23 more
TL;DR: The combination of multimodality bedside monitoring and functional brain imaging positron emission tomography and magnetic resonance, incorporated within a Neurosciences Critical Care Unit, provides the resource required to study critically ill patients after brain injury from initial ictus through recovery from coma and rehabilitation to final outcome.