Barbara Houston
University of Washington
8 Papers
28 Citations
Barbara Houston is an academic researcher from University of Washington. The author has contributed to research in topics: Insulin resistance & White adipose tissue. The author has an hindex of 6, co-authored 8 publications.
Chat about Author
Papers
Both STAT3 activation and cholesterol efflux contribute to the anti-inflammatory effect of apoA-I/ABCA1 interaction in macrophages
TL;DR: Mechanistic studies showed that the anti-inflammatory effect of the apoA-I/ABCA1/STAT3 pathway is suppressor of cytokine signaling 3 dependent, and it is suggested that the interaction of apo-I / ABCA1 activates cholesterol efflux and STAT3 branch pathways to synergistically suppress inflammation in macrophages.
55
Obesity and Weight Loss Result in Increased Adipose Tissue ABCG1 Expression in db/db Mice
Kimberly A. Edgel,Timothy S. McMillen,Hao Wei,Nathalie Pamir,Barbara Houston,Mark Caldwell,Phuong Oanh T. Mai,John F. Oram,Chongren Tang,Renee C. LeBoeuf +9 more
TL;DR: The data supports the concept that metabolic changes in adipocytes due to demand lipolysis and cell death lead to cholesterol loading of ATMs, and pathways for cholesterol trafficking out of adipose tissue involve ATM egress as well as ABCG1 mediated cholesterol efflux.
27
Hematopoietic ABCA1 deletion promotes monocytosis and worsens diet-induced insulin resistance in mice.
Chongren Tang,Yuhua Liu,Wendy Yang,Carl Storey,Timothy S. McMillen,Barbara Houston,Jay W. Heinecke,Renee C. LeBoeuf +7 more
TL;DR: An important role for hematopoietic ABCA1 is pointed to in modulating a feed-forward mechanism in obesity such that inflamed tissue macrophages stimulate the production of more monocytes, leading to an exacerbation of inflammation and associated disease processes.
13
Genetic determinants of atherosclerosis, obesity, and energy balance in consomic mice
Sabrina H. Spiezio,Lynn M. Amon,Timothy S. McMillen,Cynthia M. Vick,Barbara Houston,Mark Caldwell,Kayoko Ogimoto,Gregory J. Morton,Elizabeth A. Kirk,Michael W. Schwartz,Joseph H. Nadeau,Renee C. LeBoeuf +11 more
TL;DR: The goal here was to identify quantitative trait loci (QTLs) contributing to obesity, energy expenditure, and atherosclerosis, and identified many new QTLs and phenotyped several novel traits in this mouse model of diet-induced metabolic diseases.
Androgen receptor deficiency in monocytes/macrophages does not alter adiposity or glucose homeostasis in male mice.
Katya B. Rubinow,Barbara Houston,Shari Wang,Leela Goodspeed,Kayoko Ogimoto,Gregory J. Morton,Christopher McCarty,Robert Braun,Stephanie T. Page +8 more
TL;DR: It is suggested that AR signaling specifically in monocytes/macrophages does not contribute to the regulation of systemic energy balance, adiposity, or insulin sensitivity in male mice.
9