Barbara Bodner
Loyola University Chicago
7 Papers
23 Citations
Barbara Bodner is an academic researcher from Loyola University Chicago. The author has contributed to research in topics: Apoptosis & Prostate. The author has an hindex of 7, co-authored 7 publications.
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Papers
T cell infiltration of the prostate induced by androgen withdrawal in patients with prostate cancer
Maria Mercader,Barbara Bodner,Micheal T. Moser,Pamela S. Kwon,Eugene S. Y. Park,Ryan G. Manecke,Thomas M. Ellis,Eva M. Wojcik,Damu Yang,Robert C. Flanigan,W. Bedford Waters,W. Martin Kast,Eugene D. Kwon +12 more
TL;DR: The induction of T cell infiltration in prostate tissues treated with androgen ablation may have implications for the immunotherapeutic treatment of prostate cancer as well as other hormone-sensitive malignancies, including breast carcinoma.
401
Proteasome Inhibitors Trigger NOXA-Mediated Apoptosis in Melanoma and Myeloma Cells
Jian Zhong Qin,Jeffrey Ziffra,Lawrence S. Stennett,Barbara Bodner,Brian Bonish,Vijaya Chaturvedi,Frank C. Bennett,Pamela M. Pollock,Jeffrey M. Trent,Mary J.C. Hendrix,Paola Rizzo,Lucio Miele,Brian J. Nickoloff +12 more
TL;DR: A novel mechanism for overcoming the apoptotic resistance of tumor cells is provided, and agents triggering NOXA induction are validated as potential selective cancer therapeutics for life-threatening malignancies such as melanoma and multiple myeloma.
353
Knockdown of p53 levels in human keratinocytes accelerates Mcl-1 and Bcl-x(L) reduction thereby enhancing UV-light induced apoptosis.
Vijaya Chaturvedi,Leonid A. Sitailo,Jian Zhong Qin,Barbara Bodner,Mitchell F. Denning,Jonathan L. Curry,Wengeng Zhang,Douglas E. Brash,Brian J. Nickoloff +8 more
TL;DR: It is concluded that p53 not only can provide proapoptotic signals but also regulates a survival pathway influencing Mcl-1 and Bcl-xL levels, and opens up the possibility that not all liaisons within the cell involving p53 necessarily represent fatal attractions.
50
Defining the caspase-containing apoptotic machinery contributing to cornification in human epidermal equivalents.
TL;DR: Caspases function as important death effectors strategically positioned at intersection of intrinsic and extrinsic pathways in KCs undergoing stratum corneum formation, concluding caspase inhibitors reduced levels of involucrin and loricrin in EEs raised to an A/L interface.
26
Tumor suppressor maspin is up-regulated during keratinocyte senescence, exerting a paracrine antiangiogenic activity.
Brian J. Nickoloff,Mark W. Lingen,Bey-Dih Chang,Mei Shen,Mari E. Swift,Mari E. Swift,Jonathan L. Curry,Patricia Bacon,Barbara Bodner,Igor B. Roninson +9 more
TL;DR: Findings indicate that senescent KCs exert a paracrine antiangiogenic activity, and maspin is the principal contributor to this potentially tumor-suppressive effect of cellular senescence.