Barbara Angele
Ludwig Maximilian University of Munich
31 Papers
148 Citations
Barbara Angele is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Meningitis & Chemokine. The author has an hindex of 19, co-authored 29 publications.
Chat about Author
Papers
Complement C1q and C3 Are Critical for the Innate Immune Response to Streptococcus pneumoniae in the Central Nervous System
Tobias A. Rupprecht,Barbara Angele,Matthias Klein,Juergen Heesemann,Hans-Walter Pfister,Marina Botto,Uwe Koedel +6 more
TL;DR: It is demonstrated for the first time that the complement system plays an integral role in mounting the intense host immune response to Streptococcus pneumoniae infection of the CNS.
86
Meningitis-Associated Central Nervous System Complications Are Mediated by the Activation of Poly(ADP-ribose) Polymerase
TL;DR: Mice with a targeted disruption of the PARP1 gene were protected against meningitis-associated central nervous system complications including blood-brain barrier breaching and increase in intracranial pressure, and inhibitors of PARP activation could provide a potential therapy of acute bacterialMeningitis.
84
Acute Brain Injury Triggers MyD88-Dependent, TLR2/4-Independent Inflammatory Responses
Uwe Koedel,Ulrike Michaela Merbt,Caroline Schmidt,Barbara Angele,Bernadette Popp,Hermann Wagner,Hans-Walter Pfister,Carsten J. Kirschning +7 more
TL;DR: Modulation of the neuroinflammatory response and lesion development after aseptic cortical injury through MyD88-dependent but TLR2/4-independent signaling by central nervous system resident nonmyeloid cells is indicated.
80
Patterns of protein expression in infectious meningitis: A cerebrospinal fluid protein array analysis
TL;DR: Seventy-nine cytokines, chemokines, and growth factors were measured by protein array analysis in the cerebrospinal fluid of patients with meningitis and controls and found to be regulated, which have not been studied in the CNS before.
59
Reduced spiral ganglion neuronal loss by adjunctive neurotrophin-3 in experimental pneumococcal meningitis.
Cornelia Demel,Tobias Hoegen,Armin Giese,Barbara Angele,Hans-Walter Pfister,Uwe Koedel,Matthias Klein +6 more
TL;DR: Systemically applied NT-3 might be an interesting candidate to improve hearing outcome after pneumococcal meningitis and the success rate was comparable to that of dexamethasone.