Baoxu Pang
Leiden University Medical Center
19 Papers
Baoxu Pang is an academic researcher from Leiden University Medical Center. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 10, co-authored 13 publications. Previous affiliations of Baoxu Pang include Stanford University & Netherlands Cancer Institute.
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Papers
Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin
Baoxu Pang,Xiaohang Qiao,Lennert Janssen,Arno Velds,Tom A.M. Groothuis,Ron M. Kerkhoven,Marja Nieuwland,Huib Ovaa,Sven Rottenberg,Olaf van Tellingen,Jeroen Janssen,Peter C. Huijgens,Wilbert Zwart,Jacques Neefjes +13 more
TL;DR: It is shown that anthracyclines promote histone eviction irrespective of their ability to induce DNA double-strand breaks, which has important consequences for DNA damage responses, epigenetics, transcription, side effects and cancer therapy.
Systematic identification of silencers in human cells.
Baoxu Pang,Michael Snyder +1 more
TL;DR: It is found that silencers are widely distributed and may function in a tissue-specific fashion and probably contributes substantially to the regulation of gene expression and human biology.
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Old drugs, novel ways out: Drug resistance toward cytotoxic chemotherapeutics.
Ruud H. Wijdeven,Ruud H. Wijdeven,Baoxu Pang,Yehuda G. Assaraf,Jacques Neefjes,Jacques Neefjes +5 more
TL;DR: An overview of the molecular pathways leading to resistance against conventional anti-cancer drugs is provided, with emphasis on the utility of these pathways for rational selection of treatments for individual cancer patients.
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Gap junction-mediated intercellular communication in the immune system.
TL;DR: The current knowledge of the distribution of connexins and the function of gap junctions in the immune system is discussed and this will almost certainly expand with the increased mutual interest between the fields of immunology and gap junction research.
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Direct Antigen Presentation and Gap Junction Mediated Cross-Presentation during Apoptosis
Baoxu Pang,Joost Neijssen,Xiaohang Qiao,Lennert Janssen,Hans Janssen,Christoph Lippuner,Jacques Neefjes +6 more
TL;DR: A novel phase in classical Ag presentation and cross-presentation by MHC class I molecules is defined: presentation of Ags created by caspase activities in cells in apoptosis.
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