Methods and compositions related to the use of a protein with kynureninase activity are described. For example, in certain aspects there may be disclosed a modified kynureninase capable of degrading kynurenine. Furthermore, certain aspects of the invention provide compositions and methods for the treatment of cancer with kynurenine depletion using the disclosed proteins or nucleic acids.

Administration of kynurenine depleting enzymes for tumor therapy

The present invention relates to a cell therapeutic agent composition for preventing or treating an immune disease, the composition comprising, as an active ingredient, mesenchymal stem cells genetically modified by a recombinant vector containing the GRIM19 gene. According to the present invention, the mesenchymal stem cells genetically modified by a recombinant vector containing the GRIM19 gene can suppress the expression and production of inflammatory cytokines and proinflammatory factors, and have the ability, when co-cultured with undifferentiated T cells under pathological conditions, to promote the differentiation and activity of immunoregulatory T cells (Treg) that have the characteristic of suppressing differentiation of T cells into cytotoxic Th17 and Th1 cells, and of controlling inflammatory responses, and, in addition, to move rapidly and accurately to a pathologically affected site, and thus the mesenchymal stem cells genetically modified by a recombinant vector containing the GRIM19 gene of the present invention can be used as an active ingredient of a cell therapeutic agent composition able to prevent or treat immune diseases induced by abnormalities in regulating various immune responses.

Mesenchymal stem cells over-expressed by grim19 efficacious in treating immune disease, and use thereof

Methods for modulating immunosuppression are disclosed. This invention relates the fields of T cell regulation and therapeutic immunosuppression. More specifically, the invention provides compositions and methods for selective immunosuppressive therapies for the treatment of autoimmune diseases and allograft recipients.

Compositions and methods for modulating immunosuppression

The present invention relates to mesenchymal stem cells expressing tryptophan metabolizing enzyme genes and to an immune inhibiting composition comprising the same. More particularly, kynurenine-3-hydroxylase and kynureninase which are tryptophan metabolizing enzymes which are not naturally expressed from mesenchymal stem cells are expressed in mesenchymal stem cells, to thereby effectively inhibit alloantigen-reactive T cells of mesenchymal stem cells and thus increase immunosuppressive effects. The mesenchymal stem cells in which kynurenine-3-hydroxylase and kynureninase are expressed may provide more enhanced immunosuppressive effects than mesenchymal stem cells in which those enzymes are not expressed, and therefore, may effectively prevent and treat diseases caused by T-cell overactivation, including graft-versus-host diseases.

Immune response inhibiting composition containing stem cells expressing tryptophan metabolizing enzyme genes

The present invention relates to a composition for inhibiting metastasis, containing NecroX. NecroX inhibits the activation of Rac1 and Cdc42 or reduces the calcium concentration in cells so as to decrease the ability thereof to infiltrate cancer tissues, thereby inhibiting metastasis. The composition for inhibiting metastasis, containing NecroX, can be used as a pharmaceutical composition or a food composition for inhibiting metastasis.

Composition for inhibiting metastasis, containing necrox

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Immune response inhibiting composition containing stem cells expressing tryptophan metabolizing enzyme genes

Composition for inhibiting metastasis, containing necrox