Babu Sudhamalla
University of Pittsburgh
32 Papers
84 Citations
Babu Sudhamalla is an academic researcher from University of Pittsburgh. The author has contributed to research in topics: Chemistry & Bromodomain. The author has an hindex of 9, co-authored 20 publications. Previous affiliations of Babu Sudhamalla include University of Hyderabad.
Chat about Author
Papers
Molecular Dynamics Simulation and Binding Studies of β-Sitosterol with Human Serum Albumin and Its Biological Relevance
TL;DR: The molecular dynamics study makes an important contribution to understanding the effect of the binding of beta-sitosterol on conformational changes of HSA and the stability of a protein-drug complex system in aqueous solution.
155
RNA-Seq and molecular docking reveal multi-level pesticide resistance in the bed bug
Praveen Mamidala,Asela J. Wijeratne,Saranga Wijeratne,Karl Kornacker,Babu Sudhamalla,Loren J. Rivera-Vega,Andrew Hoelmer,Tea Meulia,Susan C. Jones,Omprakash Mittapalli +9 more
TL;DR: RNA-Seq profiles of PR strains combined with tissue-specific profiles and molecular docking revealed multi-level insecticide resistance in C. lectularius, and identified 109 putative defense genes involved in penetration resistance and metabolic resistance.
Interaction Studies of Coumaroyltyramine with Human Serum Albumin and Its Biological Importance
TL;DR: N-trans-p-coumaroyltyramine isolated from Physalis minima is a phenolic substance exhibiting many pharmacological activities like potent inhibition of acetyl cholinesterase, cell proliferation, platelet aggregation, and also antioxidant activity, which indicates the hydrophobic interactions of CT with HSA and is in well agreement with the computational calculations and molecular docking studies.
145
Site-specific azide-acetyllysine photochemistry on epigenetic readers for interactome profiling
TL;DR: In this article, a chemoproteomic approach termed interaction-based protein profiling (IBPP) is proposed to characterize novel interacting partners of potentially any reader protein, harnessing a photosensitive amino acid introduced into the hydrophobic pocket of a reader module to crosslink and enrich transient interacting partners that are inaccessible to traditional methods.
Complementary Steric Engineering at the Protein-Ligand Interface for Analogue-Sensitive TET Oxygenases.
TL;DR: This work provides a general platform for developing analogue-sensitive 2KG-dependent oxygenases to unravel their functions in diverse signaling processes and demonstrates application of the orthogonal mutant-inhibitor pair to probe transcriptional activity of a specific TET member in cells.