Babak Razani
14 Papers
Babak Razani is an academic researcher. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 1, co-authored 2 publications.
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Papers
Sustained alternate-day fasting potentiates doxorubicin cardiotoxicity.
Mualla Ozcan,Zhen Guo,Carla Valenzuela Ripoll,Ahmed Diab,Antonino Picataggi,David R. Rawnsley,A. Lotfinaghsh,Carmen Bergom,Jeffery Szymanski,Daniel H. Hwang,Aarti Asnani,Mikhail Kosiborod,Jie Zheng,Robert J. Hayashi,Pamela K. Woodard,Attila Kovacs,Kenneth B. Margulies,Joel D. Schilling,Babak Razani,Abhinav Diwan,Ali Javaheri +20 more
TL;DR: The authors showed that both sustained alternate-day fasting and a TFEB/GDF15 pathway exacerbate doxorubicin cardiotoxicity, while recombinant GDF15 was sufficient to cause cardiac atrophy.
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Identification of a leucine-mediated threshold effect governing macrophage mTOR signalling and cardiovascular risk
Xiangyu Zhang,Divya S. Kapoor,Se-Jin Jeong,A. Fappi,Jeremiah Stitham,Vasavi Shabrish,Ismail Sergin,Eman Yousif,Astrid Rodriguez-Velez,Yu-Sheng Yeh,Arick C. Park,Arif Yurdagul,Oren Rom,Slava Epelman,Joel D. Schilling,Marco Sardiello,Abhinav Diwan,Jaehyung Cho,Nathan O. Stitziel,Ali Javaheri,Irfan J. Lodhi,Bettina Mittendorfer,Babak Razani +22 more
TL;DR: Zhang et al. use human studies and mechanistic work in mouse models to describe how leucine serves as the key amino acid derived from dietary protein to drive deleterious macrophage mTORC1 signalling and promote cardiovascular disease.
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Primitive macrophages induce sarcomeric maturation and functional enhancement of developing human cardiac microtissues via efferocytic pathways
Homaira Hamidzada,Simon Pascual-Gil,Qinghua Wu,Gregory M. Kent,Stéphane Massé,Crystal Kantores,Uros Kuzmanov,M. J. Gomez-Garcia,Naimeh Rafatian,Renée A. Gorman,Marianne Wauchop,Wenliang Chen,Shira S. Landau,Tasnia Subha,Michael H. Atkins,Yimu Zhao,Erika L. Beroncal,Ian Fernandes,Jared Nanthakumar,Shabana Vohra,Erika Yan Wang,Tamilla Valdman Sadikov,Babak Razani,Tracy L. McGaha,Ana Cristina Andreazza,Anthony O. Gramolini,Peter H. Backx,Kumaraswamy Nanthakumar,Michael A. Laflamme,Gordon Keller,Milica Radisic,Slava Epelman +31 more
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Lipid-laden foam cells in the pathology of atherosclerosis: shedding light on new therapeutic targets.
Cristi L Galindo,Yu-Sheng Yeh,Babak Razani +2 more
TL;DR: As key players in atherosclerosis, foam cells are attractive targets for developing more specific, targeted therapies aimed at resolving atherosclerotic plaques.
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TMEM135 links peroxisomes to the regulation of brown fat mitochondrial fission and energy homeostasis
Donghua Hu,Min Tan,Dongliang Lu,Brian Kleiboeker,Xuejing Liu,Hongsuk Park,Alexxai V. Kravitz,Kooresh I. Shoghi,Yu-Hua Tseng,Babak Razani,Akihiro Ikeda,Irfan J. Lodhi +11 more
TL;DR: A previously unrecognized inter-organelle communication regulating mitochondrial fission and energy homeostasis is revealed and TMEM135 is identified as a potential target for therapeutic activation of BAT.
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