B. Skryabin
5 Papers
2 Citations
B. Skryabin is an academic researcher. The author has contributed to research in topics: Internal medicine & Medicine. The author has an hindex of 1, co-authored 3 publications.
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Papers
Familial atrial fibrillation mutation M1875T-SCN5A increases early sodium current and dampens the effect of flecainide
Molly O’Reilly,L C Sommerfeld,Christopher O’Shea,Sophie Broadway-Stringer,Saadia Andaleeb,J. Reyat,S N Kabir,D. Stastny,Antonia Malinova,D. Delbue,Lisa Fortmueller,Katja Gehmlich,Davor Pavlovic,B. Skryabin,A. Holmes,P. Kirchhof,Larissa Fabritz +16 more
TL;DR: In this article , the authors designed a new murine model carrying the Scn5a-M1875T mutation enabling them to study the effects of the Nav1.5 mutation in detail in vivo and in vitro using patch clamp and microelectrode recording of atrial cardiomyocytes, optical mapping, electrocardiogram, echocardiography, gravimetry, histology, and biochemistry.
Increased early sodium current provokes familial atrial fibrillation and reduces effectiveness of sodium channel block
Molly O’Reilly,L C Sommerfeld,Christopher O’Shea,Sophie Broadway-Stringer,Saadia Andaleeb,J. Reyat,S N Kabir,Antonia Malinova,Deborah Delbue,Lisa Fortmueller,Katja Gehmlich,Davor Pavlovic,B. Skryabin,A. Holmes,P. Kirchhof,Larissa Fabritz +15 more
- 20 Jan 2022
TL;DR: The Scn5a-M1875T point mutation causes a cardiac sodium channel gain-of-function and suggests increased atrial peak sodium current as a potential trigger for increased atrian excitability and atrial fibrillation.
Mechanisms of Podocyte Injury Due to Loss of the Nucleoporin NUP93.
Hussein Bachir,Vanessa Krausel,Florian Buerger,Mohamed Hamed,Barbara Heitplatz,Veerle Van Marck,Vithujan Paraparan,Hinnerk Freckmann,Samet Bayraktar,Beate Vollenbröker,Thomas Weide,Timofey S. Rozhdestvensky,B. Skryabin,Wolfram Antonin,Hermann Pavenstädt,F. Hildebrandt,Daniela A. Braun +16 more
TL;DR: Loss of NUP93 causes progressive glomerular disease in mice by impairing podocyte transcription factors, altering transcriptional programs, and leading to genomic damage, ultimately resulting in apoptosis and glomerulosclerosis.
Advancing 3Rs: The Mouse Estrus Detector (MED) as a Low-Stress, Painless, and Efficient Tool for Estrus Determination in Mice
I. V. Belozertseva,Dmitrijs D. Merkulovs,Helena Kaiser,Timofey S. Rozhdestvensky,B. Skryabin +4 more
TL;DR: Researchers evaluate the Mouse Estrus Detector (MED) for accurate estrus phase determination in mice, finding it a low-stress, painless, and efficient tool that supports the 3Rs principles, enhancing breeding strategies and reducing animal use in research.