In many nonprimate mammalian species, cyclical regression of the corpus luteum (luteolysis) is caused by the episodic pulsatile secretion of uterine PGF2α, which acts either locally on the corpus l...

Luteolysis: A Neuroendocrine-Mediated Event

Mice lacking the gene encoding the receptor for prostaglandin F2α (FP) developed normally but were unable to deliver normal fetuses at term. Although these FP-deficient mice showed no abnormality in the estrous cycle, ovulation, fertilization, or implantation, they did not respond to exogenous oxytocin because of the lack of induction of oxytocin receptor (a proposed triggering event in parturition), and they did not show the normal decline of serum progesterone concentrations that precedes parturition. Ovariectomy at day 19 of pregnancy restored induction of the oxytocin receptor and permitted successful delivery in the FP-deficient mice. These results indicate that parturition is initiated when prostaglandin F2α interacts with FP in ovarian luteal cells of the pregnant mice to induce luteolysis.

https://science.sciencemag.org/content/sci/277/5326/681.full.pdf

Failure of Parturition in Mice Lacking the Prostaglandin F Receptor

Hormone receptor control of pulsatile secretion of PGF2α from the ovine uterus during luteolysis and its abrogation in early pregnancy

Hormonal control of reproduction in small ruminants

Ovine trophoblastic protein-1 (oTP-1), an early secretory protein of the sheep blastocyst, was purified after culturing day 14–16 conceptuses for 24 h in vitro. The localization of oTP-1 in the pregnant day 16 sheep uterus was determined immunocytochemically. The protein was associated with trophectoderm cells of the elongated blastocyst and with the surface and upper glandular epithelium of the maternal uterus. Receptors that bound oTP-1 with high affinity (Kd = ∼2 × 10−10 M) were present in crude membrane preparations derived from homogenates of endometria from day 12 nonpregnant and anestrous ewes. Uterine infusion of 125I-labeled oTP-1 into day 12 nonpregnant ewes showed that the majority of the radioactivity was retained in the uterus, and only very small amounts of intact protein appeared to enter the maternal vasculature. There was no significant association with the corpora lutea, ovaries, or other tissues tested. oTP-1 failed to compete with ovine PRL for rabbit mammary gland receptors or with hC...

Ovine Trophoblast Protein 1, an Early Secreted Blastocyst Protein, Binds Specifically to Uterine Endometrium and Affects Protein Synthesis*

Prostaglandin F2α is released from the uterus of the sheep in a cyclic fashion, acts primarily in a local manner on the ovary via a counter-current mechanism and is responsible for the periodic regression of the corpus luteum in this species.

Prostaglandin F2α identified as a Luteolytic Hormone in Sheep

The physiological role of prostaglandin F2alpha in corpus luteum regression.

Handle everyday research tasks with reliable, citation-backed results

Your personal Research Agent to handle research tasks with citation-backed results

Popular Tasks used by Researchers

How can I help with your research?

Meet SciSpace

Get more enhanced response by uploading the PDFs you want me to reference.

No relevant PDFs in your library

SciSpace is the AI research assistant for academics. Run systematic literature reviews on 280M+ papers, and write papers with cited sources. Trusted by 1M+ students, PhDs & researchers.

SciSpace | AI for Research

Analyze PDFs

Code & Manuscripts

Funding & Grants

Literature & Patents

Medical & Clinical Data

Systematic Review

Visualize & Present

Web & Data

Build a Google Scholar-like website for your research.

Build a website

Create charts and images for your research

Create a Chart

Write a paper for submission to a journal

Draft a manuscript

Patent Search

Design eye-catching scientific posters in minutes.

Scientific Poster Generation

Systematic Literature Review

One task is running at the moment. Your messages will be shown right after.

Drag and drop or click here to browse

Loved by <highlight>1 million+</highlight> researchers

Extract a list of specific topics and their sources from unstructured text

Topics

Compare and analyze relevant papers that matches with your search

Papers

Get insights from PDFs and bookmarked papers from your library

My library

Recent searches

Try searching for:

Catch AI-generated content in scholarly and non-scholarly content

{ai} Detector

Ai Writer

Get PDF Summaries, highlighted text explanations 

Chat with PDF

Effortlessly create in-text citations and bibliographies in APA and 2,500 other formats

Citation generator

Get explanations, summaries, and answers on academic papers

Ease up your research workflow with {scispace}'s cohort of exciting AI tools

Elevate your academic writing skills and convey your ideas the way you want

Paraphraser

Explore our range of reading and writing tools

Your file is being prepared and should be ready in a few minutes. If it's a large file, it might take a bit longer. You can close this window, and we'll email you the file when it's done.

You have reached a maximum limit of <strong>{limit}</strong> columns in the table. Remove at least <strong>1</strong> column to add or create another one.

B. Samuelsson

Author Tools

Chat about Author

Papers

Prostaglandin F2α identified as a Luteolytic Hormone in Sheep

The physiological role of prostaglandin F2alpha in corpus luteum regression.