Chromosomal Changes in Human Tumors and Leukemias

The coexistence of monoclonal gammopathy or myeloma and nonlymphoblastic leukemia is reported in three untreated patients. One patient had IgG kappa myeloma and monoblastic leukemia, whereas the two others had IgA paraprotein in association with chronic granulocytic and acute myelomonoblastic leukemia, respectively. Simultaneous presentation of monoclonal gammopathy or myeloma and nonlymphoblastic leukemia is rare, and this report reviews the possible pathogenesis of this phenomena.

Coexistence of myelomonocytic leukemia and monoclonal gammopathy or myeloma. Simultaneous Presentation in Three Patients

A family is described in which four out of five siblings have chromosomal aberrations both in the myeloid and lymphoid cells. One of these died in the blastic phase of chronic myelogenous leukemia, another had myelofibrosis and carcinoma of the breast, a third had squamous cell carcinoma of the lip, and the other two siblings are normal. The mother had carcinoma or the breast. Two of the siblings have had occupational exposure to organic solvents. The relationship of genetic pre-disposition to malignancy, chromosomal instability, and environmental stresses is discussed.

https://acsjournals.onlinelibrary.wiley.com/doi/epdf/10.1002/1097-0142%28197401%2933%3A1%3C72%3A%3AAID-CNCR2820330114%3E3.0.CO%3B2-8

Chromosomal aberrations and neoplasm--a family study.

Preleukemia and leukemia in polycythemia vera.

Banding patterns of metaphase chromosomes in Down's syndrome.

Chromosomal Aberrations in Polycythemia Vera

Immunoglobulin levels in polycythemia vera, erythrocytosis, secondary polycythemia and myelofibrosis.

[The effects of chemical protection against radiation as reflected by aberrations of the chromosomes in the bone-marrow of mice after exposure to x-rays].

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Chromosomal Aberrations in Polycythemia Vera

Immunoglobulin levels in polycythemia vera, erythrocytosis, secondary polycythemia and myelofibrosis.

[The effects of chemical protection against radiation as reflected by aberrations of the chromosomes in the bone-marrow of mice after exposure to x-rays].