B. Küfferle
University of Vienna
39 Papers
495 Citations
B. Küfferle is an academic researcher from University of Vienna. The author has contributed to research in topics: Dopamine receptor D2 & Antipsychotic. The author has an hindex of 16, co-authored 39 publications.
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Papers
Receptor and Transporter Imaging Studies in Schizophrenia, Depression, Bulimia and Tourette's Disorder—Implications for Psychopharmacology-
Siegfried Kasper,Johannes Tauscher,Matthäus Willeit,Mara Stamenkovic,Alexander Neumeister,B. Küfferle,Christian Barnas,J. Stastny,Nicole Praschak-Rieder,Lukas Pezawas,Martina de Zwaan,S. Quiner,Walter Pirker,Susanne Asenbaum,Ivo Podreka,Thomas Brücke +15 more
TL;DR: It is demonstrated that atypical antipsychotics have a dose-dependent lower striatal D2 receptor occupancy rate compared with typical neuroleptics, paralleling the more favourable extrapyramidal side effects of atypicals antipsychotic side effects.
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In vivo 123I IBZM SPECT imaging of striatal dopamine-2 receptor occupancy in schizophrenic patients treated with olanzapine in comparison to clozapine and haloperidol
Johannes Tauscher,B. Küfferle,Susanne Asenbaum,P. Fischer,Lukas Pezawas,Christian Barnas,Sitra Tauscher-Wisniewski,Thomas Brücke,Siegfried Kasper +8 more
TL;DR: The higher striatal D2 receptor occupancy of haloperidol was correlated with the incidence and severity of extrapyramidal motor side-effects (EPS) and the degree of striatal dopamine-2 (D2) receptor occupancy in schizophrenic patients receiving clinically effective antipsychotic treatment was investigated.
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Striatal dopamine-2 receptor occupancy as measured with [123I]iodobenzamide and SPECT predicted the occurrence of EPS in patients treated with atypical antipsychotics and haloperidol
TL;DR: In vivo imaging of brain receptors with SPECT may provide a useful clinical tool to titrate doses individually and avoid motor side effects in patients treated with novel antipsychotics.
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IBZM SPECT imaging of striatal dopamine-2 receptors in psychotic patients treated with the novel antipsychotic substance quetiapine in comparison to clozapine and haloperidol.
B. Küfferle,Johannes Tauscher,Susanne Asenbaum,Christine Vesely,Ivo Podreka,Thomas Brücke,Siegfried Kasper +6 more
TL;DR: The reported data support the position that quetiapine can be considered to be an atypical antipsychotic substance due to its relatively weak striatal D2 receptor blocking property and therefore its low propensity to induce EPS.
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EEG-brain mapping in schizophrenics with predominantly positive and negative symptoms. Comparative studies with remoxipride/haloperidol.
TL;DR: The findings suggest that brain electrical signal topography is a promising method in regard to a better understanding of pathogenesis and treatment in schizophrenia.
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