16 Papers
297 Citations
B Hoet is an academic researcher from Katholieke Universiteit Leuven. The author has contributed to research in topics: Thromboxane-A synthase & Platelet. The author has an hindex of 8, co-authored 16 publications.
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Papers
Biologic effects of recombinant hirudin (CGP 39393) in human volunteers
Marc Verstraete,Michael T. Nurmohamed,J Kienast,Mathias Siebeck,Gerda Silling-Engelhardt,Harry R. Büller,B Hoet,J. Bichler,Philippe Close,Philippe Close +9 more
TL;DR: The activated partial thromboplastin time test seems to be well suited to monitor the anticoagulant effect of recombinant hirudin because the dose effect is linear up to 0.5 mg/kg of subcutaneous CGP 39393.
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Clinical pharmacology of intravenously administered recombinant desulfatohirudin (CGP 39393) in healthy volunteers.
G A Marbet,Marc Verstraete,J Kienast,P Graf,B Hoet,D.A. Tsakiris,G Silling-Engelhardt,Philippe Close +7 more
TL;DR: Clinical pharmacology of the intravenously administered recombinant desulfatohirudin CGP 39393 was investigated in 47 healthy volunteers in a multicenter study and APTT appears to be most suitable for monitoring the anticoagulant effect of C GP 39393 over a broad concentration range.
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R68070, a combined thromboxane/endoperoxide receptor antagonist and thromboxane synthase inhibitor, inhibits human platelet activation in vitro and in vivo: a comparison with aspirin
TL;DR: The drug R68070 inhibits U46619induced aggregation, blocks serum thromboxane formation, and increases serum prostaglandin (PG)E, and 6-keto-PGF1, levels, indicating that it combines throm boxane receptor blocking and thromBoxane synthase inhibiting properties.
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An echistatin-like Arg-Gly-Asp (RGD)-containing sequence in the heavy chain CDR3 of a murine monoclonal antibody that inhibits human platelet glycoprotein IIb/IIIa function.
Hans Deckmyn,Patrick Stanssens,B Hoet,Paul Declerck,Marc Lauwereys,Yannick Georges Jozef Gansemans,István Tornai,Jos Vermylen +7 more
TL;DR: Out of 30 monoclonal antibodies reacting with GPIIb/IIIa, one, MA‐16N7C2, potently inhibited platelet aggregation induced by ADP, thrombin, arachidonic acid, collagen, U46619, adrenaline and platelet‐activating factor, whereas ristocetin‐induced aggregation was unaffected.
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Sodium fluoride mimics effects of both agonists and antagonists on intact human platelets by simultaneous modulation of phospholipase C and adenylate cyclase activity.
TL;DR: It is concluded that NaF exerts a dual (stimulatory and inhibitory) effect on adenylate cyclase in intact platelets that is accompanied by simultaneous activation of a phosphoinositide-specific phospholipase C; in addition, a cAMP phosphodiesterase may be activated.
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