B. Eul
University of Giessen
32 Papers
203 Citations
B. Eul is an academic researcher from University of Giessen. The author has contributed to research in topics: Lung cancer & Medicine. The author has an hindex of 16, co-authored 22 publications.
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Papers
Hyperoxia modulates TGF-β/BMP signaling in a mouse model of bronchopulmonary dysplasia
Miguel A. Alejandre-Alcázar,Grazyna Kwapiszewska,Irwin Reiss,Oana V. Amarie,Leigh M. Marsh,Julia Sevilla-Pérez,Malgorzata Wygrecka,B. Eul,Silke Köbrich,Mareike Hesse,Ralph T. Schermuly,Werner Seeger,Oliver Eickelberg,Rory E. Morty +13 more
TL;DR: This article showed that premature infants who require oxygen therapy often develop bronchopulmonary dysplasia (BPD), a debilitating disorder characterized by pronounced alveolar hypoplasia.
242
NOX4 Regulates ROS Levels Under Normoxic and Hypoxic Conditions, Triggers Proliferation, and Inhibits Apoptosis in Pulmonary Artery Adventitial Fibroblasts
Shu Li,Sarvenaz Shafiei Tabar,Viktor Malec,B. Eul,Walter Klepetko,Norbert Weissmann,Friedrich Grimminger,Werner Seeger,Frank Rose,Jörg Hänze +9 more
TL;DR: NOX4 maintains ROS levels under normoxic and hypoxic conditions and enhances proliferation and inhibits apoptosis of PAFB and a significant increase of NOX4 mRNA expression was observed under hypoxic Conditions in PAFB from the lungs with IPAH compared to healthy donors.
130
The Angiotensin II Receptor 2 Is Expressed and Mediates Angiotensin II Signaling in Lung Fibrosis
Melanie Königshoff,Anke Wilhelm,Andreas Jahn,Daniel Sedding,Oana V. Amarie,B. Eul,Werner Seeger,Ludger Fink,Andreas Günther,Oliver Eickelberg,Frank Rose +10 more
TL;DR: It is concluded that ANGII signaling occurs primarily via AGTR1 in normal fibroblasts, while AGTR2-mediated effects are dominant on activated (myo)-fibro Blasts, a receptor switch that may perturb epithelial-mesenchymal interaction, thereby further perpetuating fibrogenesis.
121
Role of Hypoxia-Inducible Factor-1α in Hypoxia-Induced Apoptosis of Primary Alveolar Epithelial Type II Cells
Stefanie Krick,B. Eul,Jörg Hänze,Rajkumar Savai,Friedrich Grimminger,Werner Seeger,Frank Rose +6 more
TL;DR: Primary rat alveolar epithelial type II cells exposed to graded hypoxia caused a dose-dependent induction of cell cycle arrest and suppression of proliferation, which were comparable to the effects of angiotensin II, a potent inducer of ATII cell death.
100
RNA interference for HIF-1α inhibits its downstream signalling and affects cellular proliferation
Jörg Hänze,B. Eul,Rajkumar Savai,Stefanie Krick,Parag Goyal,Friedrich Grimminger,Werner Seeger,Frank Rose +7 more
TL;DR: This approach was found to suppress the shift from from S-phase to G1-phase observed in A549 cells in response to hypoxia, supporting a role of HIF-1alpha in oxygen-dependent cell cycle regulation.
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