Interferons (IFNs) comprise a heterogenous group of cytokines with pleiotropic activities. The mode of action of IFNs in human disease is still poorly understood. In particular it is not established whether IFNs exert their antineoplastic activity by direct interaction with tumor cells or indirectly by enhancing host antitumor responses. Nor is it known which biological features of a tumor and which host factors determine the sensitivity of malignant diseases to IFN therapy. In order to select IFN-α-sensitive tumor patients we have chosen Philadelphia chromosome- (Ph1)-positive chronic myelocytic leukemia (CML) as a model disease.

Strategies for Optimizing Cytokine Treatment of Malignancies: Determination of Interferon Sensitivity in Chronic Myelocytic Leukemia*

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Strategies for Optimizing Cytokine Treatment of Malignancies: Determination of Interferon Sensitivity in Chronic Myelocytic Leukemia*