Azman Abdullah
National University of Malaysia
30 Papers
117 Citations
Azman Abdullah is an academic researcher from National University of Malaysia. The author has contributed to research in topics: Vitamin E & KEAP1. The author has an hindex of 9, co-authored 26 publications. Previous affiliations of Azman Abdullah include University of Malaya & University of Liverpool.
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Papers
Proteomic analysis of Nrf2 deficient transgenic mice reveals cellular defence and lipid metabolism as primary Nrf2-dependent pathways in the liver
Neil R. Kitteringham,Azman Abdullah,Azman Abdullah,Joanne Walsh,Laura E. Randle,Rosalind E. Jenkins,Rowena L. Sison,Christopher E. Goldring,Helen Powell,Christopher M. Sanderson,Samantha J. Williams,Larry G. Higgins,Masayuki Yamamoto,John D. Hayes,B. Kevin Park +14 more
TL;DR: It is shown here for the first time, that the enzyme ATP-citrate lyase, responsible for acetyl-CoA production, is negatively regulated by NRF2, suggesting that Nrf2 is a major regulator of cellular lipid disposition in the liver.
181
•Journal Article
A review of flavonoid quercetin: Metabolism, Bioactivity and antioxidant properties
TL;DR: A review of the antioxidant and pro-oxidant effects of flavonoids can be found in this paper, where the authors focus on metabolic, bioactivity, and both antioxidant and oxidant effects.
101
Potential Role of Tocotrienols on Non-Communicable Diseases: A Review of Current Evidence
Sok Kuan Wong,Yusof Kamisah,Norazlina Mohamed,Norliza Muhammad,Norliana Masbah,Nur Azlina Mohd Fahami,Isa Naina Mohamed,Ahmad Nazun Shuid,Qodriyah Mohd Saad,Azman Abdullah,Nur-Vaizura Mohamad,Nurul 'Izzah Ibrahim,Kok-Lun Pang,Yoke Yue Chow,Benjamin Ka Seng Thong,Shaanthana Subramaniam,Chin Yi Chan,Soelaiman Ima-Nirwana,Kok-Yong Chin +18 more
TL;DR: The positive outcomes of T3 treatment obtained from the preclinical studies warrant further validation from clinical trials, particularly in prevention or treatment of non-communicable diseases (NCDs), including cardiovascular, musculoskeletal, metabolic, gastric, and skin disorders.
71
Development of a transactivator in hepatoma cells that allows expression of phase I, phase II, and chemical defense genes
Christopher E. Goldring,Neil R. Kitteringham,Rosalind E. Jenkins,Cerys A. Lovatt,Laura E. Randle,Azman Abdullah,Andrew Owen,Xiao-Ping Liu,Philip J. Butler,Dominic P. Williams,Peter Metcalfe,Christian Berens,Christian Berens,Wolfgang Hillen,Brian Foster,Alec W.M. Simpson,Lesley I. McLellan,B. Kevin Park +17 more
TL;DR: Development of hepatocyte-derived cell lines incorporating a second-generation doxycycline-inducible gene expression system and the application of the human lines to control the expression of different transgenes are demonstrated.
43
A Review of NAD(P)H:Quinone Oxidoreductase 1 (NQO1); A Multifunctional Antioxidant Enzyme -
TL;DR: The protective functions of NQO1 are discussed and its possible transcriptional pathways regulating its induction by Nrf2-Keap1/ARE pathway are presented.