Ayse Ece Gulen
4 Papers
Ayse Ece Gulen is an academic researcher. The author has contributed to research in topics: Internal medicine & Medicine. The author has co-authored 3 publications.
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Papers
Engineering donor lymphocytes with Fas ligand protein effectively prevents acute graft-versus-host disease
Pradeep Shrestha,Ali Turan,Lalita Batra,Ayse Ece Gulen,Zhen-Kui Sun,Helen Tan,Nadir Askenasy,Haval Shirwan,Esma S. Yolcu +8 more
TL;DR: The SA-FasL protein on donor lymphocytes effectively prevents acute GVHD as mentioned in this paper , but it is not shown to be effective in the case of T-cells.
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A novel agonist of 4-1BB costimulatory receptor shows therapeutic efficacy against a tobacco carcinogen-induced lung cancer
Ayse Ece Gulen,Rakesh Rudraboina,Mohammad Tarique,Vahap Ulker,Haval Shirwan,Esma S. Yolcu +5 more
TL;DR: It is suggested that immune checkpoint stimulation can be extended to a number of other cancer types, including breast and prostate cancers, for which improved diagnostics can detect disease at the preneoplastic stage.
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Abstract A007: Assessing immunoprevention efficacy of an agonist of CD137 pathway in a tobacco carcinogen-induced lung cancer preclinical model
TL;DR: Gulen et al. as discussed by the authors evaluated the immunoprevention efficacy of SA-4-1BBL in lung tumor formation induced by NNK using a preclinical model for high-risk populations.
214.3: Thrombomodulin Protein Transiently Tethered To Surface of Islets Enhance Engraftment in an Intraportal Transplantation Model by Inhibiting Peri-transplant Inflammatory Reactions
TL;DR: In this paper , a chimeric gene containing the extracellular domain of Thrombomodulin with a modified form of streptavidin (SA-TM) was generated, expressed in insect cells, and protein was characterized for structure and function.