Ayelet Rahat
Hebrew University of Jerusalem
21 Papers
500 Citations
Ayelet Rahat is an academic researcher from Hebrew University of Jerusalem. The author has contributed to research in topics: Chromosomal fragile site & Chromosome Fragile Site. The author has an hindex of 17, co-authored 21 publications.
Chat about Author
Papers
•Journal Article
The molecular basis of partial penetrance of splicing mutations in cystic fibrosis.
N Rave-Harel,Eitan Kerem,Malka Nissim-Rafinia,I Madjar,R Goshen,A. Augarten,Ayelet Rahat,A Hurwitz,Ariel Darvasi,Batsheva Kerem +9 more
TL;DR: In this article, the authors analyzed the level of correctly spliced RNA transcribed from the 5T allele in nasal and epididymal epithelium and correlated it with disease expression.
178
Homologous recombination and nonhomologous end-joining repair pathways regulate fragile site stability
Michal Schwartz,Eitan Zlotorynski,Michal Goldberg,Efrat Ozeri,Ayelet Rahat,Carlos le Sage,Benjamin P C Chen,David J. Chen,Reuven Agami,Batsheva Kerem +9 more
TL;DR: It is shown that replication stress leads to focus formation of Rad51 and phosphorylated DNA-PKcs, key components of the homologous recombination (HR) and nonhomologous end-joining, double-strand break (DSB) repair pathways, respectively.
TheMolecular Basis ofPartial Penetrance ofSplicing Mutations in Cystic Fibrosis
Eitan Kerem,Igal Madjar,Ayelet Rahat,Ariel Darvasi +3 more
- 01 Jan 1997
TL;DR: There is variability in the efficiency of the splicing mechanism, among different individuals and between different organs of the same individual, which provides the molecular basis of the partial penetrance of cystic fibrosis disease in patients carrying the 5T allele.
156
Systematic Dissection of Roles for Chromatin Regulators in a Yeast Stress Response
Assaf Weiner,Hsiuyi V. Chen,Chih Long Liu,Ayelet Rahat,Avital Klien,Luis M. Soares,Mohanram Gudipati,Jenna Pfeffner,Aviv Regev,Aviv Regev,Stephen Buratowski,Jeffrey A. Pleiss,Nir Friedman,Oliver J. Rando +13 more
- 01 Jul 2012
TL;DR: In this paper, the effects of 83 histone mutants and 119 gene deletion mutants on induction/repression dynamics of 170 transcripts in response to diamide stress in yeast were investigated.
138
Replication delay along FRA7H, a common fragile site on human chromosome 7, leads to chromosomal instability.
TL;DR: It is suggested that delayed replication is underlying the fragility at aphidicolin-induced common fragile sites and is enhancing an already existing difference in the replication time along the FRA7H region.
124