Aye T. Chen
Harvard University
10 Papers
24 Citations
Aye T. Chen is an academic researcher from Harvard University. The author has contributed to research in topics: Zebrafish & Haematopoiesis. The author has an hindex of 6, co-authored 10 publications. Previous affiliations of Aye T. Chen include Howard Hughes Medical Institute.
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Papers
A Splice Site Mutation in Laminin-α2 Results in a Severe Muscular Dystrophy and Growth Abnormalities in Zebrafish
Vandana Gupta,Genri Kawahara,Jennifer Myers,Aye T. Chen,Thomas E. Hall,Chiara Manzini,Peter D. Currie,Yi Zhou,Leonard I. Zon,Leonard I. Zon,Louis M. Kunkel,Alan H. Beggs +11 more
TL;DR: This laminin-α2 deficient mutant fish represents a novel disease model to develop therapies for modulating splicing defects in congenital muscular dystrophies and to restore the muscle function in human patients with CMD.
The zebrafish dag1 mutant: a novel genetic model for dystroglycanopathies
Vandana Gupta,Genri Kawahara,Stacey R. Gundry,Stacey R. Gundry,Aye T. Chen,Wayne I. Lencer,Yi Zhou,Leonard I. Zon,Leonard I. Zon,Louis M. Kunkel,Alan H. Beggs +10 more
TL;DR: In a forward genetic approach to identify novel genes for congenital muscle diseases, a zebrafish mutant, designated patchytail, was identified that exhibits degenerating muscle fibers with impaired motility behavior that is highly reminiscent of the phenotypes observed in the human conditions muscle-eye-brain disease and Walker-Warburg syndrome.
cpsf1 is required for definitive HSC survival in zebrafish.
Niccolo Bolli,Elspeth Payne,Elspeth Payne,Jennifer Rhodes,Evisa Gjini,Adam Johnston,Feng Guo,Jeong-Soo Lee,Rodney A. Stewart,John P. Kanki,Aye T. Chen,Yi Zhou,Leonard I. Zon,A. Thomas Look +13 more
TL;DR: Experimental studies show that cpsf1 is essential for HSC survival and differentiation in caudal hematopoietic tissue and an ethyl-nitrosourea mutagenesis screen in zebrafish shows this.
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Ccdc94 Protects Cells from Ionizing Radiation by Inhibiting the Expression of p53
Shelly Sorrells,Seth Carbonneau,Erik B. Harrington,Aye T. Chen,Bridgid E. Hast,Brett Milash,Ujwal J. Pyati,Michael B. Major,Yi Zhou,Leonard I. Zon,Rodney A. Stewart,A. Thomas Look,Cicely A. Jette +12 more
TL;DR: A new gene regulating a dosage-sensitive response to DNA DSBs during embryonic development is identified, which causes a severe sensitivity of zebrafish embryonic neurons to IR–induced apoptosis and is required for the proper development of the central nervous system.
Cleavage and Polyadenylation Specificity Factor 1 Is Required for Definitive Hematopoietic Stem Cell Survival In Zebrafish.
Niccolo Bolli,Elspeth Payne,Jennifer Rhodes,Adam Johnston,Feng Guo,Jeong-Soo Lee,John P. Kanki,Aye T. Chen,Yi Zhou,Leonard I. Zon,A. Thomas Look +10 more
TL;DR: The identification and analysis of the zebrafish mutant grechetto, caused by a lethal, recessive, inactivating mutation of the cleavage and specificity factor 1 ( cpsf1 ) gene is reported.
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