Ayappa V. Subramaniam
Universiti Sains Malaysia
5 Papers
Ayappa V. Subramaniam is an academic researcher from Universiti Sains Malaysia. The author has contributed to research in topics: Angiogenesis & Cancer. The author has an hindex of 2, co-authored 3 publications.
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Papers
The bifunctional roles of sirtuins and their therapeutic potential in cancer
Yeuan Ting Lee,Yi Jer Tan,Pei Yi Mok,Ayappa V. Subramaniam,Chern Ein Oon +4 more
- 01 Jan 2021
TL;DR: The roles of mammalian SIRTs in tumorigenesis and the development of SIRT modulators as anticancer agents are discussed.
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BZD9L1 benzimidazole analogue hampers colorectal tumor progression by impeding angiogenesis
Chern Ein Oon,Ayappa V. Subramaniam,Ashwaq Hamid Salem Yehya,Yeuan Ting Lee,Gurjeet Kaur,Sreenivasan Sasidharan,Beiying Qiu,Xiaomeng Wang +7 more
TL;DR: In this article , the anti-angiogenic potential of BZD9L1 on endothelial cells (EC) in vitro, ex vivo and in HCT116 CRC xenograft in vivo models was investigated.
1
Anti-tumour activity and toxicological studies of combination treatment of Orthosiphon stamineus and gemcitabine on pancreatic xenograft model
Ashwaq Hamid Salem Yehya,Ayappa V. Subramaniam,Muhammad Asif,Gurjeet Kaur,Amin Malik Shah Abdul Majid,Chern Ein Oon +5 more
TL;DR: In this paper , the authors evaluated the anti-tumour activity and toxicological effects of Orthosiphon stamineus extract formulation (C5EOSEW5050ESA) and gemcitabine combination on pancreatic xenograft model.
Epigenetics: The master control of endothelial cell fate in cancer.
Ayappa V. Subramaniam,Ashwaq Hamid Salem Yehya,Wei Kang Cheng,Xiaomeng Wang,Xiaomeng Wang,Xiaomeng Wang,Chern Ein Oon +6 more
TL;DR: This review aims to present an update on the latest studies on the mechanism of epigenetic modifications in angiogenesis, and examines the role of methylation of DNA, modification of histone and silencing of micro-RNA-associated gene in this process.
Angiogenesis: Managing the Culprits behind Tumorigenesis and Metastasis
Ashwaq Hamid Salem Yehya,Muhammad Asif,Sven H. Petersen,Ayappa V. Subramaniam,Koji Kono,Amin Malik Shah Abdul Majid,Chern Ein Oon +6 more
TL;DR: A complimentary combination of different agents that target multiple molecules in the angiogenic cascade may optimize inhibition of angiogenesis and improve clinical benefit in the cancer patients.