Ayami Hirata
University of Tokyo
8 Papers
36 Citations
Ayami Hirata is an academic researcher from University of Tokyo. The author has contributed to research in topics: SERCA & Haematopoiesis. The author has an hindex of 7, co-authored 8 publications.
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Papers
Crystal structures of the calcium pump and sarcolipin in the Mg2+-bound E1 state.
TL;DR: The crystal structures reported here fill a gap in the structural elucidation of the reaction cycle and provide a solid basis for understanding the physiological regulation of the calcium pump.
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Intermediate Phosphorylation Reactions in the Mechanism of ATP Utilization by the Copper ATPase (CopA) of Thermotoga maritima
TL;DR: It is proposed that Cu+ binding to the NMBD is required to produce an “active” conformation of CopA, whereby additional Cu+ bound to an alternate (transmembrane transport) site initiates faster cycles including formation of Cu·E1 ∼ P, followed by the E1 ∼P to E2-P conformational transition and hydrolytic cleavage of phosphate.
36
Sequential substitution of K(+) bound to Na(+),K(+)-ATPase visualized by X-ray crystallography.
TL;DR: X-ray crystallography results indicate that site I K+ is the first cation to bind to the empty cation-binding sites after releasing three Na+, and isotopic measurements indicate that this occurs at different rates, substantially faster at site II.
for long-term repopulating hematopoietic stem cells Junctional adhesion molecule-A, JAM-A, is a novel cell-surface marker
Atsushi Miyajima,Yasuyoshi Sugano,Masaki Takeuchi,Ayami Hirata,Hirokazu Matsushita,Toshio Kitamura +5 more
- 01 Jan 2013
TL;DR: Information about subscriptions and ASH membership may be found online at: digital object identifier (DOIs) and date of initial publication.
Junctional adhesion molecule-A, JAM-A, is a novel cell-surface marker for long-term repopulating hematopoietic stem cells
Yasuyoshi Sugano,Masaki Takeuchi,Ayami Hirata,Hirokazu Matsushita,Toshio Kitamura,Minoru Tanaka,Atsushi Miyajima +6 more
TL;DR: It is shown that JAM-A is expressed at a high level in the enriched hematopoietic stem cell (HSC) fraction; that is, CD34(+)c-Kit(+) cells in embryonic day 11.5 and Colony-forming assays reveal that multilineage colony-forming activity in JAM (+) cells is higher than that in Jam-A(-) cells in the enrichment HSC fraction in all of those tissues.