Ayako Harashima
National Institutes of Health
9 Papers
193 Citations
Ayako Harashima is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Flaccid paralysis & Poliovirus. The author has an hindex of 7, co-authored 9 publications.
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Papers
Mouse-passaged severe acute respiratory syndrome-associated coronavirus leads to lethal pulmonary edema and diffuse alveolar damage in adult but not young mice.
Noriyo Nagata,Naoko Iwata,Hideki Hasegawa,Shuetsu Fukushi,Ayako Harashima,Yuko Sato,Masayuki Saijo,Fumihiro Taguchi,Shigeru Morikawa,Tetsutaro Sata +9 more
TL;DR: An animal model using BALB/c mice and the mouse-passaged Frankfurt 1 isolate of SARS coronavirus is developed and shows early and acute excessive proinflammatory responses in the lungs after SARS-CoV infection, which led to severe pulmonary edema and diffuse alveolar damage.
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Participation of both Host and Virus Factors in Induction of Severe Acute Respiratory Syndrome (SARS) in F344 Rats Infected with SARS Coronavirus
Noriyo Nagata,Naoko Iwata,Hideki Hasegawa,Shuetsu Fukushi,Masaru Yokoyama,Ayako Harashima,Yuko Sato,Masayuki Saijo,Shigeru Morikawa,Tetsutaro Sata +9 more
TL;DR: The results strongly indicate that host and virus factors such as advanced age and virus adaptation are critical for the development of SARS in rats.
A poliomyelitis model through mucosal infection in transgenic mice bearing human poliovirus receptor, TgPVR21
Noriyo Nagata,Takuya Iwasaki,Takuya Iwasaki,Yasushi Ami,Yuko Sato,Ikuyoshi Hatano,Ayako Harashima,Yuriko Suzaki,Takao Yoshii,Tsutomu Hashikawa,Tetsutaro Sata,Yoshinobu Horiuchi,Satoshi Koike,Takeshi Kurata,Akio Nomoto +14 more
TL;DR: Transgenic mice bearing the human poliovirus receptor (TgPVR) are less susceptible to oral inoculation, although they are susceptible to parenteral inoculation; this model can be used as a mucosal infection model and for differentiation of neurovirulent and attenuated poliov virus strains.
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Comparison of neuropathogenicity of poliovirus type 3 in transgenic mice bearing the poliovirus receptor gene and cynomolgus monkeys.
Noriyo Nagata,Takuya Iwasaki,Yasushi Ami,Ayako Harashima,Ikuyoshi Hatano,Yuriko Suzaki,Kumiko Yoshii,Takao Yoshii,Akio Nomoto,Takeshi Kurata +9 more
TL;DR: The results confirmed the reliability of neurovirulence tests using TgPVR21 as a substitute for monkeys, in respect to the spinal and brainstem lesions of poliovirus type 3.
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Thimerosal Induces Toxic Reaction in Non-Sensitized Animals
Tetsuya Uchida,Seishiro Naito,Hiroshi Kato,Ikuyoshi Hatano,Ayako Harashima,Yuki Terada,Tokitada Ohkawa,Fumitoshi Chino,Komyo Eto +8 more
TL;DR: Thimerosal contained as a preservative in vaccine may augment the side-effects of the vaccination, suggesting that part of these hypersensitivity reactions against thimerosal observed among patients were possibly induced by the toxic effect of thimerosa.
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