Axelle Strehle
French Institute of Health and Medical Research
9 Papers
Axelle Strehle is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Intellectual disability & G protein-coupled bile acid receptor. The author has an hindex of 5, co-authored 5 publications. Previous affiliations of Axelle Strehle include Centre national de la recherche scientifique.
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Papers
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas,Antimo Gioiello,Lilia G. Noriega,Lilia G. Noriega,Axelle Strehle,Julien Oury,Giovanni Rizzo,Antonio Macchiarulo,Hiroyasu Yamamoto,Hiroyasu Yamamoto,Chikage Mataki,Chikage Mataki,Mark Pruzanski,Roberto Pellicciari,Johan Auwerx,Johan Auwerx,Kristina Schoonjans,Kristina Schoonjans +17 more
TL;DR: It is shown here that TGR5 signaling induces intestinal glucagon-like peptide-1 (GLP-1) release, leading to improved liver and pancreatic function and enhanced glucose tolerance in obese mice, and suggested that pharmacological targeting of T GR5 may constitute a promising incretin-based strategy for the treatment of diabesity and associated metabolic disorders.
1.7K
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Metabolic Disorders by Enhancing Fat Oxidation
Jerome N. Feige,Marie Lagouge,Carles Cantó,Axelle Strehle,Sander M. Houten,Jill C. Milne,Philip D. Lambert,Chikage Mataki,Peter J. Elliott,Johan Auwerx,Johan Auwerx +10 more
TL;DR: The metabolic phenotype of mice treated with SRT1720, a specific and potent synthetic activator of SIRT1 that is devoid of direct action on AMPK that robustly enhances endurance running performance and strongly protects from diet-induced obesity and insulin resistance by enhancing oxidative metabolism in skeletal muscle, liver, and brown adipose tissue is reported.
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Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
Hiroyuki Sato,Cédric Genet,Axelle Strehle,Axelle Strehle,Charles Thomas,Annelise Lobstein,Alain Wagner,Charles Mioskowski,Johan Auwerx,Régis Saladin +9 more
TL;DR: The isolation and the identification of another constituent implicated in the anti-diabetic effect of olive leaves are described, i.e. oleanolic acid, and it is shown that this triterpene is an agonist for TGR5, a member of G-protein coupled receptor activated by bile acids and which mediates some of their various cellular and physiological effect.
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Redefining the TGR5 triterpenoid binding pocket at the C-3 position
Cédric Genet,Céline Schmidt,Axelle Strehle,Kristina Schoonjans,Johan Auwerx,Régis Saladin,Alain Wagner +6 more
TL;DR: The structure-activity relationships between terpenoids and type 2 diabetes, and triterpenes and Derivatives Reference EPFL-ARTICLE-165507 are studied to propose a new strategy for quantifying the importance of these relationships to health.
27
GenIDA: an international participatory database to gain knowledge on health issues related to genetic forms of neurodevelopmental disorders
Pauline Burger,Florent Colin,Axelle Strehle,Timothée Mazzucotelli,Nicole Collot,Romain Coutelle,B. Durand,A. C. Bouman,Daphna Landau Prat,Tjitske Kleefstra,Pierre Parrend,Amélie Piton,David A. Koolen,Jean-Louis Mandel +13 more
TL;DR: GenIDA as mentioned in this paper is an online participatory database that aims to better characterise the clinical manifestations and natural histories of these rare diseases, which often remain insufficiently described in terms of clinical spectrum, associated medical problems, etc., due to their rarity and the often limited number of patients' phenotypes reported.