Avner Schlessinger
Icahn School of Medicine at Mount Sinai
51 Papers
172 Citations
Avner Schlessinger is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Virtual screening & Amino acid. The author has an hindex of 17, co-authored 51 publications.
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Papers
SLC Transporters: Structure, Function, and Drug Discovery.
TL;DR: An overview of the SLC transporters' structures and transport mechanisms is provided and computational techniques, such as homology modeling and virtual screening that are emerging as key tools to discover chemical probes for human SLC members are described.
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Molecular Basis for Redox Activation of Epidermal Growth Factor Receptor Kinase.
Thu H. Truong,Peter Man-Un Ung,Prakash B. Palde,Candice E. Paulsen,Avner Schlessinger,Kate S. Carroll +5 more
TL;DR: It is shown that chronic oxidative stress yields an EGFR subpopulation that is refractory to the FDA-approved drug afatinib, and the significance of redox biology to understanding kinase regulation and drug pharmacology is highlighted.
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Loss-of-function variants of SETD5 cause intellectual disability and the core phenotype of microdeletion 3p25.3 syndrome
Alma Kuechler,Alexander M. Zink,Thomas Wieland,Hermann-Josef Lüdecke,Kirsten Cremer,Leonardo Salviati,Pamela Magini,Kimia Najafi,Christiane Zweier,Johanna Christina Czeschik,Stefan Aretz,Sabine Endele,Federica Tamburrino,Claudia Pinato,Maurizio Clementi,Jasmin Gundlach,Carina Maylahn,Laura Mazzanti,Eva Wohlleber,Thomas Schwarzmayr,Roxana Kariminejad,Avner Schlessinger,Dagmar Wieczorek,Tim M. Strom,Gaia Novarino,Hartmut Engels +25 more
TL;DR: Exome analysis revealed de novo intragenic variants in SET domain-containing 5 (SETD5) in two patients and CRISPR/Cas9 mutation modelling demonstrated nonsense-mediated decay of the resulting transcripts, pointing to a loss-of-function (LoF) and haploinsufficiency as the common disease-causing mechanism of intragenics SETD5 sequence variants and SETD 5-containing microdeletions.
SLC classification: an update.
Avner Schlessinger,Sook Wah Yee,Sook Wah Yee,Andrej Sali,Andrej Sali,Kathleen M. Giacomini,Kathleen M. Giacomini +6 more
TL;DR: This work comprehensively compare the SLC sequences and structures and discusses the applicability of structure‐based ligand discovery to key SLC members.
Coordinating the impact of structural genomics on the human α-helical transmembrane proteome
Ursula Pieper,Avner Schlessinger,Edda Kloppmann,Geoffrey Chang,James J. Chou,Mark E. Dumont,Brian G. Fox,Petra Fromme,Wayne A. Hendrickson,Michael G. Malkowski,Douglas C. Rees,David L. Stokes,Michael H. B. Stowell,Michael C. Wiener,Burkhard Rost,Robert M. Stroud,Raymond C. Stevens,Andrej Sali,Andrej Sali +18 more
TL;DR: This work explores the tractability of determining representatives for the entire human membrane proteome, and proposes structures of 100 optimally selected targets to increase the fraction of modelable human α-helical transmembrane domains from 26% to 58%.
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