Austin L. LaGrow
University of Oklahoma Health Sciences Center
16 Papers
39 Citations
Austin L. LaGrow is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Endophthalmitis & Bacillus cereus. The author has an hindex of 7, co-authored 12 publications.
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Papers
Targets of immunomodulation in bacterial endophthalmitis.
Frederick C. Miller,Phillip S. Coburn,Mursalin Md Huzzatul,Austin L. LaGrow,Erin Livingston,Michelle C. Callegan +5 more
TL;DR: It is suggested that host immune mediators are important components of the response to infections in the posterior segment of the eye, and the timing and level of their production may be related to the severity of the damage and the ultimate visual outcome.
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A Novel Biomimetic Nanosponge Protects the Retina from the Enterococcus faecalis Cytolysin
Austin L. LaGrow,Phillip S. Coburn,Frederick C. Miller,Craig Land,Salai Madhumathi Parkunan,Brian T. Luk,Weiwei Gao,Liangfang Zhang,Michelle C. Callegan +8 more
- 22 Nov 2017
TL;DR: It is demonstrated that biomimetic nanosponges neutralize cytolysin, protect the retina, preserve vision, and may provide an adjunct detoxification therapy for bacterial infections, as well as suggesting that this novel strategy might also protect eyes from the activities of pore-forming toxins of other virulent ocular bacterial pathogens.
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TLR4 modulates inflammatory gene targets in the retina during Bacillus cereus endophthalmitis.
Phillip S. Coburn,Frederick C. Miller,Austin L. LaGrow,Salai Madhumathi Parkunan,C. Blake Randall,Rachel L. Staats,Michelle C. Callegan +6 more
TL;DR: The results have identified a cohort of mediators driven by TLR4 that may be important in regulating pro-inflammatory and protective pathways in the retina in response to B. cereus intraocular infection.
The role of pili in Bacillus cereus intraocular infection.
Michelle C. Callegan,Salai Madhumathi Parkunan,C. Blake Randall,Phillip S. Coburn,Frederick C. Miller,Austin L. LaGrow,Roger A. Astley,Craig Land,So-Young Oh,Olaf Schneewind +9 more
TL;DR: A potential role for pili is suggested in protecting B. cereus from clearance during the early stages of endophthalmitis, which is a newly described virulence mechanism for this organism and this infection.
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Expression of Bacillus cereus Virulence-Related Genes in an Ocular Infection-Related Environment.
Phillip S. Coburn,Frederick C. Miller,Morgan A Enty,Craig Land,Austin L. LaGrow,Huzzatul Mursalin,Michelle C. Callegan +6 more
- 22 Apr 2020
TL;DR: Gene expression in ex vivo vitreous humor with expression in Luria Bertani and Brain Heart Infusion broth is compared by RNA-Seq to report that the PlcR/PapR system regulates intraocular virulence, but the specific factors that contribute to B. cereus virulence in the eye remain elusive.
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