Audrius Paskevicius
Lund University
23 Papers
93 Citations
Audrius Paskevicius is an academic researcher from Lund University. The author has contributed to research in topics: Transplantation & Heart preservation. The author has an hindex of 9, co-authored 21 publications.
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Papers
Consistent success in life-supporting porcine cardiac xenotransplantation
Matthias Längin,Tanja Mayr,Bruno Reichart,Sebastian Michel,Stefan Buchholz,Sonja Guethoff,Alexey Dashkevich,Andrea Baehr,Stefanie Egerer,Andreas Bauer,Maks Mihalj,Alessandro Panelli,Lara Issl,Jiawei Ying,Ann Kathrin Fresch,Ines Buttgereit,Maren Mokelke,Julia Radan,Fabian Werner,I. Lutzmann,Stig Steen,Trygve Sjöberg,Audrius Paskevicius,Liao Qiuming,Riccardo Sfriso,Robert Rieben,Maik Dahlhoff,Barbara Kessler,Elisabeth Kemter,Mayuko Kurome,Valeri Zakhartchenko,Katharina Klett,Katharina Klett,Rabea Hinkel,Rabea Hinkel,Christian Kupatt,Almuth Falkenau,Simone Reu,Reinhard Ellgass,Rudolf Herzog,Uli Binder,Günter Wich,Arne Skerra,David Ayares,Alexander Kind,Uwe Schönmann,Franz-Josef Kaup,Christian Hagl,Eckhard Wolf,Nikolai Klymiuk,Paolo Brenner,Jan-Michael Abicht +51 more
TL;DR: It is shown that α1,3-galactosyltransferase-knockout pig hearts that express human CD46 and thrombomodulin require non-ischaemic preservation with continuous perfusion and post-transplantation growth control to ensure long-term orthotopic function of the xenograft in baboons, the most stringent preclinical xenotransplantation model.
435
Safe orthotopic transplantation of hearts harvested 24 hours after brain death and preserved for 24 hours.
TL;DR: Orthotopic transplantation of porcine donor hearts harvested 24’hours after brain death and preserved for 24 hours can be done safely, and the adrenaline test showed a dose dependent response.
118
A nonrandomized open-label phase 2 trial of nonischemic heart preservation for human heart transplantation.
Johan Nilsson,Victoria Jernryd,Guangqi Qin,Audrius Paskevicius,Carsten Metzsch,Trygve Sjöberg,Stig Steen +6 more
TL;DR: This first-in-human study shows the feasibility and safety of NIHP for clinical use in heart transplantation in a non-randomized trial and shows that ischemia and reperfusion damage contribute to early graft dysfunction and recipient’s death.
93
Pig-to-non-human primate heart transplantation: The final step toward clinical xenotransplantation?
Bruno Reichart,Matthias Längin,Julia Radan,Maren Mokelke,Ines Buttgereit,Jiawei Ying,Ann Kathrin Fresch,Tanja Mayr,Lara Issl,Stefan Buchholz,Sebastian Michel,Reinhard Ellgass,Maks Mihalj,Stefanie Egerer,Andrea Baehr,Barbara Kessler,Elisabeth Kemter,Mayuko Kurome,Valeri Zakhartchenko,Stig Steen,Trygve Sjöberg,Audrius Paskevicius,Luise Krüger,Uwe Fiebig,Joachim Denner,Antonia W. Godehardt,Ralf R. Tönjes,Anastasia Milusev,Robert Rieben,Riccardo Sfriso,Christoph Walz,Thomas Kirchner,David Ayares,Karen Lampe,Uwe Schönmann,Christian Hagl,Eckhard Wolf,Nikolai Klymiuk,Jan-Michael Abicht,Paolo Brenner +39 more
TL;DR: The results of the current and previous experimental cardiac xenotransplantations together fulfill for the first time the pre-clinical efficacy suggestions, and PCMV-positive donor animals must be avoided.
75
Manual versus mechanical cardiopulmonary resuscitation. An experimental study in pigs
TL;DR: LUCAS-CPR gave significantly higher coronary perfusion pressure and significantly fewer rib fractures than manual CPR in this porcine model.