Audrey Nédélec
French Institute of Health and Medical Research
7 Papers
Audrey Nédélec is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Functional Effects of PTPN11 (SHP2) Mutations Causing LEOPARD Syndrome on Epidermal Growth Factor-Induced Phosphoinositide 3-Kinase/AKT/Glycogen Synthase Kinase 3β Signaling
Thomas Edouard,Jean-Philippe Combier,Audrey Nédélec,Sophie Bel-Vialar,Mélanie Métrich,Francoise Conte-Auriol,Francoise Conte-Auriol,Stanislas Lyonnet,Béatrice Parfait,Maithé Tauber,Maithé Tauber,Jean-Pierre Salles,Jean-Pierre Salles,Frank Lezoualc'h,Armelle Yart,Patrick Raynal,Patrick Raynal +16 more
TL;DR: ShP2 mutations causing LS facilitate EGF-induced PI3K/AKT/GSK-3β stimulation through impaired GAB1 dephosphorylation, resulting in deregulation of a novel signaling pathway that could be involved in LS pathology.
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Secreted Mutant Calreticulins As Rogue Cytokines in Myeloproliferative Neoplasms.
Christian Pecquet,Nicolas Papadopoulos,Thomas Balligand,Ilyas Chachoua,Amandine Tisserand,Gaëlle Vertenoeil,Audrey Nédélec,Didier Vertommen,Anita Roy,Caroline Marty,Harini Nivarthi,Jean-Philippe Defour,Mira El-Khoury,Eva Hug,Andrea Majoros,Erica Xu,Oleh Zagrijtschuk,Tudor Emanuel Fertig,Daciana S. Marta,Heinz Gisslinger,Bettina Gisslinger,Martin Schalling,Ilaria Carola Casetti,Elisa Rumi,Daniela Pietra,Chiara Cavalloni,Luca Arcaini,Mario Cazzola,Norio Komatsu,Yoshihiko Kihara,Yoshitaka Sunami,Yoko Edahiro,Marito Araki,Roman Lesyk,Veronika Buxhofer-Ausch,Sonja Heibl,Florence Pasquier,Isabelle Plo,William Vainchenker,Robert Kralovics,Stefan N. Constantinescu +40 more
TL;DR: In this article , mutant calreticulin (CALR) proteins resulting from a -1/-2 frameshifting mutation of the CALR exon 9 carry a novel C-terminal amino acid sequence and drive the development of myeloproliferative neoplasms (MPNs).
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Oncogenic CALR mutant C-terminus mediates dual binding to the thrombopoietin receptor triggering complex dimerization and activation
Nicolas Papadopoulos,Audrey Nédélec,Allison Derenne,Teodor Asvadur Şulea,Christian Pecquet,Ilyas Chachoua,Gaëlle Vertenoeil,Thomas Tilmant,Andrei J. Petrescu,Gabriel Mazzucchelli,Bogdan I. Iorga,Didier Vertommen,Stefan N. Constantinescu +12 more
TL;DR: In this paper , the authors identify the basis of the acquired specificity of CALR mutants for TpoR and define the mechanisms by which complex formation triggers TPOR dimerization and activation.
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Modulation of Human Thrombopoietin Receptor Conformations Uncouples JAK2 V617F-Driven From Cytokine-Induced Activation.
Nicolas Papadopoulos,Ajda Pristavec,Audrey Nédélec,Gabriel Levy,Judith Staerk,Stefan N. Constantinescu +5 more
TL;DR: Modulation of hTpoR conformation is demonstrated to be a viable therapeutic strategy for JAK2 V617F positive MPNs and set the path for novel drug development by identifying precise residues of h TpoR involved in JAK1 V617f specific activation.
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Penttinen syndrome‐associated PDGFRB Val665Ala variant causes aberrant constitutive STAT1 signalling
Audrey Nédélec,Emilie Guérit,Guillaume Dachy,Sandrine Lenglez,Lok San Wong,Florence A. Arts,Jean-Baptiste Demoulin +6 more
TL;DR: The p.Val665Ala variant associated with Penttinen syndrome at the molecular level was characterized in this paper , where it was shown that the substitution is located in a conserved loop of the receptor tyrosine kinase domain.
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