Audrey Ncube
University of Düsseldorf
12 Papers
30 Citations
Audrey Ncube is an academic researcher from University of Düsseldorf. The author has contributed to research in topics: Induced pluripotent stem cell & Transcriptome. The author has an hindex of 6, co-authored 12 publications.
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Papers
The FGF, TGFβ and WNT axis Modulate Self-renewal of Human SIX2 + Urine Derived Renal Progenitor Cells
Shaifur Rahman,Wasco Wruck,Lucas-Sebastian Spitzhorn,Lisa Nguyen,Martina Bohndorf,Soraia Martins,Fatima Asar,Audrey Ncube,Lars Erichsen,Nina Graffmann,James Adjaye +10 more
TL;DR: The urine-derived renal progenitor cells and the data presented should lay the foundation for studying nephrogenesis in human, as well as upregulation of WNT-associated genes- AXIN2, JUN and NKD1.
The presence of human mesenchymal stem cells of renal origin in amniotic fluid increases with gestational time.
Shaifur Rahman,Lucas-Sebastian Spitzhorn,Wasco Wruck,Carsten Hagenbeck,Percy Balan,Nina Graffmann,Martina Bohndorf,Audrey Ncube,Pascale V. Guillot,Tanja Fehm,James Adjaye +10 more
TL;DR: Third-trimester amniotic fluid contains AF-MSCs of renal origin and this novel source of kidney progenitors may have enormous future potentials for disease modeling, renal repair and drug screening.
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A stem cell based in vitro model of NAFLD enables the analysis of patient specific individual metabolic adaptations in response to a high fat diet and AdipoRon interference.
Nina Graffmann,Audrey Ncube,Soraia Martins,Aurelian Robert Fiszl,Philipp Reuther,Martina Bohndorf,Wasco Wruck,Mathias Beller,Constantin Czekelius,James Adjaye +9 more
TL;DR: In this paper, induced pluripotent stem cells (iPSCs) derived from four distinct donors with varying disease stages were differentiated into hepatocyte like cells (HLCs) and determined fat storage as well as metabolic adaptations after stimulations with oleic acid.
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Transcriptomic analysis of marine endophytic fungi extract identifies highly enriched anti-fungal fractions targeting cancer pathways in HepG2 cell lines
Ethel J. S. Blessie,Wasco Wruck,Benaiah Annertey Abbey,Audrey Ncube,Nina Graffmann,Vincent Amarh,Patrick K. Arthur,James Adjaye,James Adjaye +8 more
TL;DR: The purified fractions from MEF investigated in this study showed antifungal activity against C. albicans and S. cerevisiae alone or both and reduced proliferation of the human liver cancer cell line HepG2 implicating regulation of several cancer- and metabolism-related pathways.
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Establishment and characterization of an iPSC line from a 35 years old high grade patient with nonalcoholic fatty liver disease (30-40% steatosis) with homozygous wildtype PNPLA3 genotype.
Nina Graffmann,Martina Bohndorf,Audrey Ncube,Marie-Ann Kawala,Wasco Wruck,Karl Kashofer,Kurt Zatloukal,James Adjaye +7 more
TL;DR: Reprogrammed fibroblasts of a high grade NAFLD patient with homozygous wildtype PNPLA3 genotype were reprogrammed and induced pluripotent stem cells (iPSCs) were characterized by immunocytochemistry, flow cytometry, embryoid body formation, pluritest, DNA-fingerprinting and karyotype analysis.
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