Audrey C. Papp
The Ohio State University Wexner Medical Center
9 Papers
12 Citations
Audrey C. Papp is an academic researcher from The Ohio State University Wexner Medical Center. The author has contributed to research in topics: Gene & Transcriptome. The author has an hindex of 7, co-authored 9 publications.
Chat about Author
Papers
A Novel In Vitro Human Granuloma Model of Sarcoidosis and Latent Tuberculosis Infection.
Elliott D. Crouser,Peter White,Evelyn Guirado Caceres,Mark W. Julian,Audrey C. Papp,Landon W. Locke,Wolfgang Sadee,Larry S. Schlesinger +7 more
TL;DR: An in vitro model of granuloma formation using human peripheral blood mononuclear cells derived from patients with active sarcoidosis, latent tuberculosis (TB) infection (LTBI), or normal healthy control subjects is proposed as a tool to investigate mechanisms of early granulomas formation and for preclinical drug discovery research of human granulomatous disorders.
IL-13-regulated Macrophage Polarization during Granuloma Formation in an In Vitro Human Sarcoidosis Model.
Landon W. Locke,Elliott D. Crouser,Peter White,Mark W. Julian,Evelyn Guirado Caceres,Audrey C. Papp,Van T Le,Wolfgang Sadee,Larry S. Schlesinger +8 more
TL;DR: The in vitro human sarcoidosis granuloma model provides novel insights into early granulomas formation, particularly IL‐13 regulation of molecular networks that regulate M2 macrophage polarization.
Whole transcriptome RNA-Seq allelic expression in human brain
Ryan M. Smith,Amy Webb,Audrey C. Papp,Leslie C. Newman,Samuel K. Handelman,Adam Suhy,Roshan Mascarenhas,John Oberdick,Wolfgang Sadee +8 more
TL;DR: This post-transcriptional process is under heavy regulatory influence to maintain an optimal degree of editing for normal biological function and provides a foundation for using this technology to screen allelic RNA expression on a transcriptome-wide basis.
Transcriptomic variation of pharmacogenes in multiple human tissues and lymphoblastoid cell lines
Aparna Chhibber,Courtney E. French,Sook Wah Yee,Eric R. Gamazon,Elizabeth Theusch,Xiang Qin,Amy Webb,Audrey C. Papp,Ann Wang,Christine Q. Simmons,Anuar Konkashbaev,Amarjit S. Chaudhry,Katrina Mitchel,Doug Stryke,Thomas E. Ferrin,Scott T. Weiss,Deanna L. Kroetz,Wolfgang Sadee,Deborah A. Nickerson,Ronald M. Krauss,Alfred L. George,Erin G. Schuetz,Marisa W. Medina,Nancy J. Cox,Steven E. Scherer,Kathleen M. Giacomini,Steven E. Brenner +26 more
TL;DR: Analysis of RNA-seq data from 139 different individuals across the 5 tissues revealed substantial variation in both expression levels and splicing across samples and tissue types, and revealed 183 splicing events in pharmacogenes that were previously not annotated.
Allele-Selective Transcriptome Recruitment to Polysomes Primed for Translation: Protein-Coding and Noncoding RNAs, and RNA Isoforms
Roshan Mascarenhas,Maciej Pietrzak,Ryan M. Smith,Amy Webb,Danxin Wang,Audrey C. Papp,Julia K. Pinsonneault,Michal Seweryn,Grzegorz A. Rempala,Wolfgang Sadee +9 more
TL;DR: Allele-selective polysome recruitment revealed strong genetic influence for multiple RNAs, attributable either to differential expression of RNA isoforms or to differential loading onto polysomes, the latter defining a direct genetic effect on translation.