Effect of exercise-based cardiac rehabilitation on anxiety and depression in patients with myocardial infarction: A systematic review and meta-analysis.

https://opus.lib.uts.edu.au/bitstream/10453/114865/4/Correlates%20of%20health-related%20quality%20of%20life%20in%20patients%20with%20myocardial%20infarction%20A%20literature%20review.pdf

Correlates of health-related quality of life in patients with myocardial infarction: A literature review

Objective Individuals who experience myocardial infarction (MI) often experience anxiety. Green tea has potent antioxidative properties and, epigallocatechin-3-gallate (EGCG), which is a primary component of tea polyphenols, has advantageous effects on anxiety and depression. However, its mechanism of action regarding the inhibition of anxiety-like symptoms after MI remains unclear. This study examined whether EGCG alleviated anxiety-like behavior in MI rats and its possible mechanism. Material and methods Rats were administered a daily gavage of EGCG (50 mg/kg) 7 days before and 14 consecutive days after the MI procedure. The open-field test and light/dark shuttle box were performed to evaluate anxiety-like behavior. Serum and hippocampus interleukin (IL)-6 levels were tested using ELISA. Caspase 3, caspase 8, caspase 9 and bcl-2 messenger RNA levels in the hippocampus were determined using quantitative polymerase chain reaction, and STAT3 protein was detected by Western blot. Results Results of the open field test and light/dark shuttle box task demonstrated that the MI procedure induced anxiety-like behavior in the animals, and this impairment was improved by EGCG. Daily EGCG administration significantly decreased the level of IL-6 both in serum and hippocampus after MI. The administration of EGCG also significantly moderated the expression of caspases 3, 8, and 9 mRNA, which was related to apoptosis in the hippocampus. Furthermore, EGCG also downregulated the expression of STAT3, which was related to the activity of IL-6. These results suggest that EGCG alleviated anxiety-like behavior by inhibiting increases in neuroinflammation and apoptosis in the rat hippocampus. In addition, EGCG reversed alterations of IL-6 and STAT3 in the brain to alleviate apoptosis in the hippocampus. Conclusions Thus, EGCG reversed anxiety-like behavior through an anti-inflammation effect to alleviate apoptosis in neurons and may be a useful therapeutic material for anxiety-like behavior after MI.

https://onlinelibrary.wiley.com/doi/pdf/10.1002/brb3.1633

Protective effect of epigallocatechin‐3‐gallate against neuroinflammation and anxiety‐like behavior in a rat model of myocardial infarction

This study aims to investigate health-related quality of life (HRQoL) of Korean patients in the acute phase of myocardial infarction (MI) and correlates of this important patient outcome. A total of 150 patients with recent MI were recruited. The Korean version of the MacNew Quality of Life after Myocardial Infarction Questionnaire was used to assess their HRQoL. Demographic, behavioural and disease-related factors were also assessed and the Depression, Anxiety and Stress Scale (DASS 21) was used for psychological well-being. Participants who had a higher education level and better financial status had better HRQoL. Diabetes, history of stroke, other heart disease and a higher score of the DASS 21 were adversely associated with HRQoL. The findings of this study help identify risk factors that are related to lower HRQoL after MI. Early psychological and financial support may help reduce the impact of MI on patients' overall health and quality of life.

/pdf/health-related-quality-of-life-and-its-predictors-in-korean-3pv4qwr7px.pdf

Health-related Quality of Life and Its Predictors in Korean Patients with Myocardial Infarction in the Acute Phase.

Job burnout predicts decline of health-related quality of life among employees with cardiovascular disease: A one-year follow-up study in female nurses.

Aims and objectives. To examine psychological risk factors and somatic factors in patients after myocardial infarction. To study the relationship between somatic and psychological factors, their influence on subjective quality of life (well-being) and also to examine possible gender differences. Background. There has been a growing body of evidence that psychosocial factors are risk factors for incident and recurrent myocardial infarction. Design. Descriptive correlational and cross-sectional survey design. Methods. In patients (n = 97, 67 men), the level of depression and anxiety, vital exhaustion, sleep disturbances and well-being were assessed. Left ventricular ejection fraction, left ventricular diastolic diameter, body mass index, metabolic equivalents and the number of diseased vessels were retrieved from medical records. Results. Anxiety, vital exhaustion and sleep disturbances were significantly higher in women than in men. Well-being showed a significant linear correlation with body mass index, anxiety, depression, vital exhaustion and sleep disturbances scores. After adjustment for psychological risk factors and somatic parameters, only vital exhaustion and anxiety correlated significantly with well-being. However, there were gender differences in predictive variables of well-being. Anxiety in men and vital exhaustion in women showed a linear correlation with the subjective quality of life. Conclusion. Our study revealed that only vital exhaustion and anxiety showed a significant correlation with well-being in patients. Relevance to clinical practice. During cardiac rehabilitation, it is important to detect and treat not only depression but also vital exhaustion and anxiety, because by reducing these psychological conditions, we can improve well-being.

Vital exhaustion and anxiety are related to subjective quality of life in patients with acute myocardial infarct before cardiac rehabilitation.

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Vital exhaustion and anxiety are related to subjective quality of life in patients with acute myocardial infarct before cardiac rehabilitation.