Atsushi Hirao
Kanazawa University
132 Papers
785 Citations
Atsushi Hirao is an academic researcher from Kanazawa University. The author has contributed to research in topics: Stem cell & Haematopoiesis. The author has an hindex of 46, co-authored 121 publications. Previous affiliations of Atsushi Hirao include University of Toronto & Cancer Research Institute.
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Papers
Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche
Fumio Arai,Atsushi Hirao,Masako Ohmura,Hidetaka Sato,Sahoko Matsuoka,Keiyo Takubo,Keisuke Ito,Gou Young Koh,Toshio Suda +8 more
TL;DR: It is demonstrated that HSCs expressing the receptor tyrosine kinase Tie2 are quiescent and antiapoptotic, and comprise a side-population (SP) of H SCs, which adhere to osteoblasts (OBs) in the BM niche.
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DNA damage-induced activation of p53 by the checkpoint kinase Chk2.
Atsushi Hirao,Young-Yun Kong,Shuhei Matsuoka,Andrew Wakeham,Jürgen Ruland,Hiroki Yoshida,Dou Liu,Stephen J. Elledge,Tak W. Mak +8 more
TL;DR: Chk2 directly phosphorylated p53 on serine 20, which is known to interfere with Mdm2 binding, and provides a mechanism for increased stability of p53 by prevention of ubiquitination in response to DNA damage.
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Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells.
Keisuke Ito,Atsushi Hirao,Atsushi Hirao,Fumio Arai,Keiyo Takubo,Sahoko Matsuoka,Kana Miyamoto,Masako Ohmura,Masako Ohmura,Kazuhito Naka,Kentaro Hosokawa,Yasuo Ikeda,Toshio Suda +12 more
TL;DR: In this paper, the authors show that activation of p38 MAPK in response to increasing levels of reactive oxygen species (ROS) limits the lifespan of HSCs in vivo.
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Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells
Keisuke Ito,Atsushi Hirao,Fumio Arai,Sahoko Matsuoka,Keiyo Takubo,Isao Hamaguchi,Kana Nomiyama,Kentaro Hosokawa,Kazuhiro Sakurada,Naomi Nakagata,Yasuo Ikeda,Tak W. Mak,Toshio Suda +12 more
TL;DR: It is shown that ATM has an essential function in the reconstitutive capacity of haematopoietic stem cells (HSCs) but is not as important for the proliferation or differentiation of progenitors, in a telomere-independent manner.
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Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy.
Yoshinobu Ichimura,Satoshi Waguri,Yu-shin Sou,Shun Kageyama,Jun Hasegawa,Ryosuke Ishimura,Tetsuya Saito,Yinjie Yang,Tsuguka Kouno,Toshiaki Fukutomi,Takayuki Hoshii,Atsushi Hirao,Kenji Takagi,Tsunehiro Mizushima,Hozumi Motohashi,Myung-Shik Lee,Tamotsu Yoshimori,Keiji Tanaka,Masayuki Yamamoto,Masaaki Komatsu +19 more
TL;DR: It is shown that phosphorylation of the autophagy-adaptor protein p62 markedly increases p62's binding affinity for Keap1, an adaptor of the Cul3-ubiquitin E3 ligase complex responsible for degrading Nrf2, and that inhibitors of the interaction between phosphorylated p62 and Keap 1 have potential as therapeutic agents against human HCC.
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