Atif Towheed

TL;DR: In this article , the authors found evidence that OxPhos defects increase resting energy expenditure, a state termed hypermetabolism, which is associated with mitochondrial DNA instability, activation of the integrated stress response (ISR), and increased extracellular secretion of age-related cytokines and metabokines including GDF15.

TL;DR: The strikingly different phenotypic effects of these mild mtDNA variants demonstrate that mtDNA can be an important modulator of autosomal disease and demonstrate that nuclear-encoded mutations can modulate the expressivity of nuclear DNA -encoded diseases.

TL;DR: This work endeavour to provide a balanced view of mitochondrial respiratory control and a critical discussion on reporting data of mitochondrial respiration in terms of metabolic flows and fluxes.

TL;DR: The error rate of RNA polymerase II ranges from 2.9 × 10-6 ± 1.9 in yeast to 4.0 × 10 −6 ± 5.9 −8/bp in human cells as mentioned in this paper .