Athurva Gore
University of California, San Diego
26 Papers
52 Citations
Athurva Gore is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Biology & Induced pluripotent stem cell. The author has an hindex of 16, co-authored 24 publications.
Chat about Author
Papers
Somatic coding mutations in human induced pluripotent stem cells
Athurva Gore,Zhe Li,Ho Lim Fung,Jessica E. Young,Suneet Agarwal,Jessica Antosiewicz-Bourget,Isabel Canto,Alessandra Giorgetti,Mason A. Israel,Evangelos Kiskinis,Je-Hyuk Lee,Yuin-Han Loh,Philip D. Manos,Nuria Montserrat,Athanasia D. Panopoulos,Sergio Ruiz,Melissa L. Wilbert,Junying Yu,Ewen F. Kirkness,Juan Carlos Izpisua Belmonte,Derrick J. Rossi,James A. Thomson,Kevin Eggan,George Q. Daley,Lawrence S.B. Goldstein,Kun Zhang +25 more
TL;DR: It is shown that 22 human induced pluripotent stem (hiPS) cell lines reprogrammed using five different methods each contained an average of five protein-coding point mutations in the regions sampled, and that hiPS cells acquire genetic modifications in addition to epigenetic modifications.
Whole-Genome Sequencing in Autism Identifies Hot Spots for De Novo Germline Mutation
Jacob J. Michaelson,Yujian Shi,Madhusudan Gujral,Hancheng Zheng,Dheeraj Malhotra,Xin Jin,Minghan Jian,Guangming Liu,Douglas S. Greer,Abhishek Bhandari,Wenting Wu,Roser Corominas,Aine Peoples,Aine Peoples,Amnon Koren,Athurva Gore,Shuli Kang,Guan Ning Lin,Jasper A. Estabillo,Therese E. Gadomski,Balvindar Singh,Kun Zhang,Natacha Akshoomoff,Christina Corsello,Steven A. McCarroll,Lilia M. Iakoucheva,Yingrui Li,Jun Wang,Jun Wang,Jonathan Sebat +29 more
TL;DR: This article investigated global patterns of germline mutation by whole-genome sequencing of monozygotic twins concordant for ASD and their parents and found that hypermutability is a property of ASD genes and may also include nucleotide substitution hot spots.
578
Targeted bisulfite sequencing reveals changes in DNA methylation associated with nuclear reprogramming
Jie Deng,Robert Shoemaker,Bin Xie,Athurva Gore,Emily M LeProust,Jessica Antosiewicz-Bourget,Dieter Egli,Nimet Maherali,In-Hyun Park,Junying Yu,George Q. Daley,Kevin Eggan,Konrad Hochedlinger,James A. Thomson,Wei Li Wang,Yuan Gao,Kun Zhang +16 more
TL;DR: A method to specifically capture an arbitrary subset of genomic targets for single-molecule bisulfite sequencing for digital quantification of DNA methylation at single-nucleotide resolution is reported.
573
Non-invasive early detection of cancer four years before conventional diagnosis using a blood test.
Xingdong Chen,Jeffrey A. Gole,Athurva Gore,He Qiye,Ming Lu,Ming Lu,Jun Min,Ziyu Yuan,Xiaorong Yang,Xiaorong Yang,Yanfeng Jiang,Tiejun Zhang,Chen Suo,Xiaojie Li,Lei Cheng,Zhenhua Zhang,Hongyu Niu,Zhe Li,Zhen Xie,Han Shi,Xiang Zhang,Min Fan,Xiaofeng Wang,Yajun Yang,Justin Dang,Catie McConnell,Juan Zhang,Jiucun Wang,Shun-Zhang Yu,Weimin Ye,Weimin Ye,Yuan Gao,Kun Zhang,Rui Liu,Li Jin +34 more
TL;DR: It is demonstrated that cancer can be non-invasively detected up to four years before current standard of care and patients whose disease is diagnosed in its early stages have better outcomes.
Somatic coding mutations in human induced pluripotent stem cells
Athurva Gore,Zhe Li,Ho-Lim Fung,J. Young,Suneet Agarwal,Jessica Antosiewicz-Bourget,Isabel Canto,Alessandra Giorgetti,Mason A. Israel,Evangelos Kiskinis,Je-Hyuk Lee,Yuin-Han Loh,Philip D. Manos,Nuria Montserrat,Athanasia D. Panopoulos,Sergio Ruiz,Melissa Wilbert,Junying Yu,E. Kirkness,Juan Carlos Izpisua Belmonte,Derrick J. Rossi,James Thomson,Kevin Eggan,George Q. Daley,Lawrence S.B. Goldstein,Kun Zhang +25 more
TL;DR: It is shown that 22 human induced pluripotent stem (hiPS) cell lines reprogrammed using five different methods each contained an average of five protein-coding point mutations in the regions sampled, and that hiPS cells acquire genetic modifications in addition to epigenetic modifications.
516