Aswin Hari
University of Calgary
10 Papers
13 Citations
Aswin Hari is an academic researcher from University of Calgary. The author has contributed to research in topics: Dendritic cell & T cell. The author has an hindex of 10, co-authored 10 publications. Previous affiliations of Aswin Hari include University of Ottawa & Ottawa Hospital Research Institute.
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Papers
Alum interaction with dendritic cell membrane lipids is essential for its adjuvanticity
Tracy L. Flach,Gilbert Ng,Aswin Hari,Melanie D. Desrosiers,Ping Zhang,Sandra Ward,Mark E. Seamone,Akosua Vilaysane,Ashley D. Mucsi,Yin Fong,Elmar J. Prenner,Chang-Chun Ling,Jürg Tschopp,Daniel A. Muruve,Matthias Amrein,Yan Shi +15 more
TL;DR: This study reports that, independent of inflammasome and membrane proteins, alum binds dendritic cell (DC) plasma membrane lipids with substantial force and proposes that alum triggers DC responses by altering membrane lipid structures.
411
Inflammatory Flt3l is essential to mobilize dendritic cells and for T cell responses during Plasmodium infection
Pierre Guermonprez,Julie Helft,Carla Claser,Stephanie Deroubaix,Henry Karanje,Anna Gazumyan,Guillaume Darasse-Jèze,Stephanie B. Telerman,Gaëlle Breton,Heidi A. Schreiber,Natalia Frias-Staheli,Eva Billerbeck,Marcus Dorner,Charles M. Rice,Alexander Ploss,Florian Klein,Melissa Swiecki,Marco Colonna,Alice O. Kamphorst,Matthew M. Meredith,Rachel E. Niec,Constantin N. Takacs,Fadi Mikhail,Aswin Hari,David Bosque,Tom Eisenreich,Tom Eisenreich,Miriam Merad,Yan Shi,Florent Ginhoux,Laurent Rénia,Britta C. Urban,Britta C. Urban,Michel C. Nussenzweig,Michel C. Nussenzweig +34 more
TL;DR: An innate sensing pathway triggered by Plasmodium infection that regulates dendritic cell homeostasis and adaptive immunity through Flt3 ligand (Flt3l) release is described and found that type I IFN supports the upregulation of xanthine dehydrogenase.
160
Activation of NLRP3 inflammasome by crystalline structures via cell surface contact
Aswin Hari,Yifei Zhang,Zhongyuan Tu,Pascal Detampel,Melanie D. Stenner,Anutosh Ganguly,Yan Shi +6 more
TL;DR: It is provided evidence to suggest that macrophage cell membrane binding to immobilized crystals was sufficient to induce IL-1β release, and this activation of the NLRP3 inflammasome was inhibited by blocking potassium efflux.
Toll-Like Receptors: Role in Dermatological Disease
TL;DR: The association between TLRs and various skin pathologies is described and proposed TLR therapeutics are discussed to link the innate and adaptive immune systems.
Loss of IRF2BP2 in Microglia Increases Inflammation and Functional Deficits after Focal Ischemic Brain Injury.
Shelly A. Cruz,Shelly A. Cruz,Aswin Hari,Aswin Hari,Zhaohong Qin,Zhaohong Qin,Pascal Couture,Pascal Couture,Hua Huang,Hua Huang,Diane C. Lagace,Alexandre F.R. Stewart,Hsiao-Huei Chen +12 more
TL;DR: It is shown that loss of IRF2BP2 in microglia leads to increased inflammatory cytokine expression in response to lipopolysaccharide challenge and impaired activation of anti-inflammatory markers in Response to interleukin-4 (IL4) stimulation.